所有图片(1)
About This Item
经验公式（希尔记法）:
C27H26N4O2
CAS号:
分子量:
438.52
MDL编号:
UNSPSC代码:
12352111
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
synthetic (organic)
质量水平
方案
≥97% (Mixture of 2 isomers)
表单
powder
溶解性
DMSO: soluble
ethanol: soluble
运输
dry ice
储存温度
−20°C
SMILES字符串
CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26
InChI
1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
InChI key
LBFDERUQORUFIN-UHFFFAOYSA-N
应用
Bisindolylmaleimide II (BIS II) has been used:
- as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
- as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
- as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells
生化/生理作用
Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes during cerebral ischemia. The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS)
Binh Thanh Nguyen et al.
Electrophoresis, 37(23-24), 3146-3153 (2016-10-27)
An assay for protein kinase C delta (PKCδ) activity based on the quantification of a synthetic substrate using capillary electrophoresis with laser-induced fluorescence detection was developed. The peptides labeled with fluorescein isothiocyanate F-ERK (where ERK is extracellular signal-regulated kinase) and
Ameneh Cheshmehkani et al.
Biochemical pharmacology, 146, 139-150 (2017-09-26)
Agonism of the G protein-coupled free-fatty acid receptor-4 (FFA4) has been shown to promote numerous anti-inflammatory effects in macrophages that arise due to interaction with β-arrestin partner proteins. Humans express functionally distinct short and long FFA4 splice variants, such that
Petr Heneberg et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49(1), 54-67 (2018-10-06)
CD16 was previously suggested to be a new marker of basophils that is subject to downregulation by FcεRI crosslinking. Certain compounds, including supraoptimal concentrations of the PKC inhibitors, bisindolylmaleimides, decouple the release of granules containing CD203c, CD63 and histamine, and
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