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Merck
CN
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安全信息

B2809

Sigma-Aldrich

抗菌肽

≥95% (HPLC)

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About This Item

经验公式（希尔记法）:
C63H118N24O13S2
分子量:
1483.89
MDL编号:
MFCD00236810
UNSPSC代码:
51102829
PubChem化学物质编号:
329773208
NACRES:
NA.85

质量水平

200

方案

≥95% (HPLC)

表单

powder

溶解性

1 mg/mL (in 1% TFA in H20)

抗生素抗菌谱

Gram-negative bacteria

作用机制

cell membrane | interferes

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(N)=N

InChI

1S/C63H118N24O13S2/c1-13-34(11)46-57(97)78-38(21-17-25-75-62(69)70)49(89)83-43(31(5)6)54(94)82-42(53(93)79-39(59(99)100)22-18-26-76-63(71)72)29-102-101-28-41(81-51(91)40(27-30(3)4)80-48(88)36(64)19-15-23-73-60(65)66)52(92)77-37(20-16-24-74-61(67)68)50(90)86-47(35(12)14-2)58(98)85-44(32(7)8)55(95)84-45(33(9)10)56(96)87-46/h30-47H,13-29,64H2,1-12H3,(H,77,92)(H,78,97)(H,79,93)(H,80,88)(H,81,91)(H,82,94)(H,83,89)(H,84,95)(H,85,98)(H,86,90)(H,87,96)(H,99,100)(H4,65,66,73)(H4,67,68,74)(H4,69,70,75)(H4,71,72,76)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1

InChI key

RHISNKCGUDDGEG-CJMCYECYSA-N

Amino Acid Sequence

Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg-OH (Disulfide bridge: 3-11)

一般描述

化学结构：肽

应用

Bactenecin的活性已被作为环状分子以其线性形式而得以研究。它已被用于研究Trk1p在其他抗真菌肽机制中的功能作用。它已被用于研究趋化因子和细胞因子的产生、宿主细胞中基因表达的改变以及宿主细胞对细菌成分的促炎反应的抑制。

生化/生理作用

Bactenecin是一种来自牛中性粒细胞的含12个氨基酸的阳离子抗菌肽。它可与LPS牢固结合并扰乱其内膜的结构、流动性和渗透性。这会导致细胞溶质的泄漏和随后的细菌死亡。

其他说明

肽类抗生素，最初从牛中性粒细胞颗粒中分离的
保存于密闭容器内，置于干燥通风处。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCG0473
SLCC1786
SLCB3648
SLCB0199
SLBK9705V

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Dawn M E Bowdish et al.
Antimicrobial agents and chemotherapy, 49(5), 1727-1732 (2005-04-28)
Recent studies have demonstrated that in addition to their antimicrobial activity, cationic host defense peptides, like the human cathelicidin LL-37, perform many activities relating to innate immunity, including the induction or modulation of chemokine and cytokine production, alteration of gene
M Wu et al.
The Journal of biological chemistry, 274(1), 29-35 (1998-12-29)
Bactenecin, a 12-amino acid cationic antimicrobial peptide from bovine neutrophils, has two cysteine residues, which form one disulfide bond, making it a cyclic molecule. To study the importance of the disulfide bond, a linear derivative Bac2S was made and the
D Romeo et al.
The Journal of biological chemistry, 263(20), 9573-9575 (1988-07-15)
Cytoplasmic granules of neutrophils store a variety of cationic polypeptides, which exert in vitro a potent antibacterial action and are potentially involved in host defense mechanisms. From an acid extract of bovine neutrophil granules we have purified over 2,000-fold a
B Gallis et al.
Biotechnology therapeutics, 1(4), 335-346 (1989-01-01)
Bactenecin is an antimicrobial peptide isolated from bovine neutrophils. Bactenecin was synthesized by solid-phase peptide synthesis and renatured to a fully disulfide bonded form. The peptide inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration reported
Shirley M Halling et al.
Current microbiology, 56(3), 274-278 (2008-01-25)
Intracellular pathogens selected for increased susceptibility to polycations are commonly attenuated, yet the effect of decreased susceptibility to polycations on pathogenicity has not been researched. The polymyxin-resistant mutant Brucella abortus AJ100 was characterized by comparing its susceptibility to the polycationic
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