B2515
L-丁硫氨酸亚砜亚胺
synthetic (organic), ≥97% (TLC), γ-glutamylcysteine synthetase inhibitor, powder
别名:
L-BSO
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关于此项目
经验公式（希尔记法）:
C8H18N2O3S
化学文摘社编号:
分子量:
222.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
2367136
产品名称
L-丁硫氨酸亚砜亚胺, ≥97% (TLC)
biological source
synthetic (organic)
Quality Level
assay
≥97% (TLC)
form
powder
mp
224-226 °C
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
shipped in
wet ice
storage temp.
−20°C
SMILES string
CCCCS(=N)(=O)CC[C@H](N)C(O)=O
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
InChI key
KJQFBVYMGADDTQ-CVSPRKDYSA-N
Gene Information
human ... GCLC(2729), GCLM(2730)
Application
L丁硫氨酸-亚砜亚胺已用作：
- 选择性激活剂，以诱导大鼠凋亡细胞的铁死亡
- γ谷氨酰半胱氨酸合成酶抑制剂，以研究其对小黑麦和大麦小孢子胚胎发生（ME）诱导活力和效果的影响
- 谷胱甘肽合成阻断剂，以研究其在小鼠肺泡巨噬细胞中金诺芬（AFN）介导的白介素-1β表达的影响
用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。
Biochem/physiol Actions
通过抑制谷胱甘肽生物合成中的关键酶γ-谷氨酰半胱氨酸合成酶，进而阻断对化疗的细胞抵抗性。用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance.
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Journal of magnetic resonance (San Diego, Calif. : 1997), 276, 31-36 (2017-01-17)
Thiol redox status is an important physiologic parameter that affects the success or failure of cancer treatment. Rapid scan electron paramagnetic resonance (RS EPR) is a novel technique that has shown higher signal-to-noise ratio than conventional continuous-wave EPR in in
Triticale and barley microspore embryogenesis induction requires both reactive oxygen species generation and efficient system of antioxidative defence
Zur I, et al.
Plant Cell, Tissue and Organ Culture, 145(2), 347-366 (2021)
Zeyu Cao et al.
Scientific reports, 7(1), 16278-16278 (2017-11-28)
Enterovirus 71 (EV71) is a key pathogen of hand, foot and mouth disease (HFMD) in children under 6 years of age. The antiviral potency of antioxidant isochlorogenic acid C (ICAC) extracted from foods was evaluated in cellular and animal models.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B2515-5G | 04061833426845 |
| B2515-1G | 04061833426821 |
| B2515-500MG | 04061833426838 |