B2133
N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride
protease substrate, chromogenic, ≥97% (HPLC), powder
别名:
Bz-Pro-Phe-Arg-p-nitroanilide hydrochloride, Bz-Pro-Phe-Arg-pNA hydrochloride
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关于此项目
经验公式（希尔记法）:
C33H38N8O6 · HCl
化学文摘社编号:
分子量:
679.17
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride, protease substrate
SMILES string
Cl.NC(=N)NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C2CCCN2C(=O)c3ccccc3)C(=O)Nc4ccc(cc4)N(=O)=O
InChI
1S/C33H38N8O6.ClH/c34-33(35)36-19-7-13-26(29(42)37-24-15-17-25(18-16-24)41(46)47)38-30(43)27(21-22-9-3-1-4-10-22)39-31(44)28-14-8-20-40(28)32(45)23-11-5-2-6-12-23;/h1-6,9-12,15-18,26-28H,7-8,13-14,19-21H2,(H,37,42)(H,38,43)(H,39,44)(H4,34,35,36);1H
InChI key
OGYWLWIIQPDFPW-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
solubility
methanol: 25 mg/mL
storage temp.
−20°C
Quality Level
General description
A chromogenic substrate for Agkistrodon contortrix thrombin-like enzyme and plasma kallikrein.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
W Dick et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 19(6), 357-361 (1981-06-01)
A chromogenic assay for the determination of factor XII using the chromogenic substrate Chromozym PK was evaluated. The assay was linear in the range 10 U/l to more than 200 U/l. Using the assay, the normal range of factor XII
K Nishikawa et al.
Biochemical pharmacology, 43(6), 1361-1369 (1992-03-17)
Bradykinin (BK), an important mediator of allergic reactions and pain induction, is released by the activation of the plasma kallikrein-kinin (K-K) cascade. Neurotropin is a biological material obtained from inflamed rabbit skin inoculated with vaccinia virus and is widely used
G Claeson et al.
Haemostasis, 7(2-3), 62-68 (1978-01-01)
Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates
G Vogel et al.
Folia haematologica (Leipzig, Germany : 1928), 109(1), 115-120 (1982-01-01)
The kallikrein specific chromogenic peptide substrates S-2302 (KABI) and Chromozym PK (Boehringer) were used in the first analysis of a familial defect in the early stage of clotting. Slight to extensive prolongation of the activated partial thromboplastin time was seen
Determination of factor XII in plasma using the kallikrein substrate chromozym PK.
C Klessen et al.
Thrombosis research, 25(6), 501-505 (1982-03-15)
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