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Merck
CN

B1636

Sigma-Aldrich

五肽胃泌素

≥95% (HPLC), powder, CCK2 receptor agonist

别名:

五肽促胃酸激素, 五肽胃泌素, N-t-Boc-β-Ala-Trp-Met-Asp-Phe酰胺

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About This Item

经验公式(希尔记法):
C37H49N7O9S
CAS号:
分子量:
767.89
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

product name

五肽胃泌素, ≥95% (HPLC), powder

质量水平

检测方案

≥95% (HPLC)

形式

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white to off-white

溶解性

DMF: 20 mg/mL, clear, colorless to faint yellow or tan

储存温度

−20°C

SMILES字符串

CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O

InChI

1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)

InChI key

NEYNJQRKHLUJRU-UHFFFAOYSA-N

基因信息

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Amino Acid Sequence

Boc-Bal-Trp-Met-Asp-Phe-NH2

一般描述

适合研究领域:免疫学 & 细胞因子

应用

五肽胃泌素已被用于双向调节杏仁核外侧核(LA)的活力。在AR42J大鼠胰腺细胞系中,可阻断胆囊收缩素2受体(CCK2R)激动剂抑制受体与Ga-DOTA-MGS5的结合,进行细胞摄取和受体结合研究。

生化/生理作用

五肽胃泌素为人工合成的胃泌素类似物,肽链羧基末端五肽的结构与天然胃泌素一样。可作为胆囊收缩素-2(CCK2)受体/胆囊收缩素-B(CCKB)受体的激动剂。五肽胃泌素可促进胃蛋白酶和胃酸分泌,适合用于胃酸分泌功能检查。五肽胃泌素具有惊恐和焦虑作用,会导致惊恐症(PD)患者的惊恐发作。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is Pentagastrin, Product B1636, soluble in?

    Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.

  4. How can Pentagastrin, Product B1636, solutions be stored?

    Pentagastrin is subject to oxidation in solution.  A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.

  5. What is the shelf-life of Pentagastrin, Product B1636?

    This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Gilbert H Daniels
Thyroid : official journal of the American Thyroid Association, 21(11), 1199-1207 (2011-09-23)
Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy with the potential for aggressive behavior. Measurement of serum calcitonin (Ct) in the thyroid nodule population is the most sensitive way to detect occult MTC. An important and controversial question is
Pentagastrin as a stimulant in routine clinical testing of gastric acid secretion.
S A Pedersen
Digestion, 3(2), 81-89 (1970-01-01)
Géraldine Pina et al.
Clinical endocrinology, 78(3), 358-364 (2012-08-24)
To evaluate a second-generation assay for basal serum calcitonin (CT) measurements compared with the pentagastrin-stimulation test for the diagnosis of inherited medullary thyroid carcinoma (MTC) and the follow-up of patients with MTC after surgery. Recent American Thyroid Association recommendations suggest
Anton A Hörmann et al.
Pharmaceuticals (Basel, Switzerland), 14(6) (2021-07-03)
The new minigastrin analog DOTA-MGS5 is a promising new candidate for targeting cholecystokinin-2 receptor (CCK2R)-expressing tumors. To enable the clinical translation of PET/CT imaging using 68Ga-labeled DOTA-MGS5, different quality and safety aspects need to be considered to comply with the
Functional, Diagnostic and Therapeutic Aspects of Gastrointestinal Hormones
Ahmed M and Ahmed S
Gastroenterology Research and Practice, 233-244 (2019)

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