B1532
Resorufin benzyl ether
CYP450 substrate, ≥98% (TLC), powder
别名:
7-Benzyloxy-3H-phenoxazin-3-one, 7-Benzyloxyresorufin, O7-Benzylresorufin
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关于此项目
经验公式（希尔记法）:
C19H13NO3
化学文摘社编号:
分子量:
303.31
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
Resorufin benzyl ether, CYP450 substrate
SMILES string
O=C1C=CC2=Nc3ccc(OCc4ccccc4)cc3OC2=C1
InChI
1S/C19H13NO3/c21-14-6-8-16-18(10-14)23-19-11-15(7-9-17(19)20-16)22-12-13-4-2-1-3-5-13/h1-11H,12H2
InChI key
XNZRYTITWLGTJS-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
solubility
chloroform: 9.80-10.20 mg/mL, clear, orange
storage temp.
2-8°C
Quality Level
General description
Fluorimetric substrate for cytochrome P450-linked enzymes.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
H Y Yang et al.
Molecular pharmacology, 46(5), 922-928 (1994-11-01)
Expression of functional cytochrome P450 (CYP) isoforms in human embryonic tissues was explored during organogenesis (days 50-60 of gestation) with substrate probes, inhibitor probes, and immunoprobes and by reverse transcription-polymerase chain reaction (PCR), cloning, and sequencing. Evidence was obtained for
Y Lin et al.
Drug metabolism and disposition: the biological fate of chemicals, 29(4 Pt 1), 368-374 (2001-03-22)
Most cytochrome P450 (P450 or CYP)-catalyzed reactions are adequately described by classical Michaelis-Menten kinetic parameters (e.g., Km and Vmax), which are usually determined by a saturation profile of velocity of product formation versus substrate concentration. In turn, these parameters may
Lukas Rutz et al.
Archives of toxicology, 94(12), 4159-4172 (2020-09-11)
1,2-unsaturated pyrrolizidine alkaloids (PAs) are natural plant constituents comprising more than 600 different structures. A major source of human exposure is thought to be cross-contamination of food, feed and phytomedicines with PA plants. In humans, laboratory and farm animals, certain
Benzyloxyresorufin as a specific substrate for the major phenobarbital-inducible dog liver cytochrome P450 (P4502B11).
P A Klekotka et al.
Drug metabolism and disposition: the biological fate of chemicals, 23(12), 1434-1435 (1995-12-01)
Nantana Nuchtavorn et al.
Analytica chimica acta, 1098, 86-93 (2020-01-18)
Cytochrome P450 (CYP450), and in particular CYP3A4, is the most abundantly expressed CYP450 isozyme implicated in many drug-drug and medicinal plant-drug interactions. Therefore, incorporation of CYP3A4 enzyme screening at an early stage of drug discovery is preferable in order to
商品
Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.
一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。
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