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Merck
CN

B107

Sigma-Aldrich

L-BMAA 盐酸盐

≥97% (NMR), powder

别名:

S(+)-2-氨基-3-(甲基氨基)丙酸 盐酸盐

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About This Item

经验公式(希尔记法):
C4H10N2O2 · HCl
CAS号:
分子量:
154.60
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32

质量水平

方案

≥97% (NMR)

表单

powder

旋光性

[α]/D +21 to +31°, c = 0.5 M in 0.1 M HCl(lit.)

储存条件

desiccated

颜色

white to beige

溶解性

H2O: soluble (solutions may be stored for several days at 4 °C)

储存温度

−20°C

SMILES字符串

Cl.CNC[C@H](N)C(O)=O

InChI

1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1

InChI key

VDXYGASOGLSIDM-DFWYDOINSA-N

一般描述

L-BMAA 盐酸盐/ β-N-甲基氨基-1-丙氨酸(BMAA)是一种蓝藻神经毒素(cyanobacterial neurotoxin)。

应用

L-BMAA 盐酸盐可用作标准品,用于比较沙漠结皮(desert crust)材料的β-N-甲基氨基-1-丙氨酸(BMAA)异构体分析中的所有样品。它也已被用作f/2+Sii培养基的添加剂,用于处理三角藻(Phaeodyylum tricornutum)和威氏海链藻 (Thalassiosira weissflogii)细胞,以研究其对它们的作用。

生化/生理作用

L-BMAA盐酸盐有助于阻止硫酸乙酰肝素加入磷脂酰肌醇蛋白聚糖。它具有不同寻常的谷氨酸受体结合特性。它可引起肌萎缩性侧索硬化症/ Lou Gehrig′病。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

David A Davis et al.
Journal of neuropathology and experimental neurology, 79(4), 393-406 (2020-02-23)
The early neuropathological features of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are protein aggregates in motor neurons and microglial activation. Similar pathology characterizes Guamanian ALS/Parkinsonism dementia complex, which may be triggered by the cyanotoxin β-N-methylamino-l-alanine (BMAA). We report here the
Neurotoxic amino acids and their isomers in desert environments
Metcalf JS, et al.
Journal of arid environments, 140-144 (2015)
Olga A Koksharova et al.
Toxins, 12(6) (2020-06-10)
All cyanobacteria produce a neurotoxic non-protein amino acid β-N-methylamino-L-alanine (BMAA). However, the biological function of BMAA in the regulation of cyanobacteria metabolism still remains undetermined. It is known that BMAA suppresses the formation of heterocysts in diazotrophic cyanobacteria under nitrogen
Beta-N-methylamino-L-alanine (L-BMAA) is a potent agonist of 'metabolotropic' glutamate receptors.
A Copani et al.
European journal of pharmacology, 181(3), 327-328 (1990-06-08)
Boyin Yan et al.
Chemosphere, 243, 125355-125355 (2019-11-24)
Cyanobacteria produce a series of secondary metabolites, one of which is beta-N-methylamino-l-alanine (BMAA). BMAA is considered to be the cause of human neurodegeneration. Compared with other cyanotoxins, the role of BMAA in cyanobacteria remains unclear. To investigate this question, six

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