推荐产品
质量水平
形式
solid
溶解性
DMSO: 5 mg/mL
chloroform: soluble(lit.)
ethyl acetate: soluble(lit.)
methanol: soluble(lit.)
methylene chloride: soluble(lit.)
储存温度
−20°C
SMILES字符串
Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c4ccccc4
InChI
1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChI key
LZAXPYOBKSJSEX-GOSISDBHSA-N
一般描述
(−)-布雷他汀，一种II型肌球蛋白ATP酶抑制剂，不影响I、V和X型等肌球蛋白超家族的其他成员。布雷他汀具有高度光敏性， 并且光漂白可以完全逆转其效果。布雷他汀是一种心血管生理学中常用的激发-收缩解偶联剂。布雷他汀可控制凝血酶对细胞间Ca2+波传播的抑制作用。布雷他汀通过稳定粗肌丝的OFF状态来降低心脏的收缩性。
应用
(?)-布雷他汀已被用于研究对心肌收缩力的影响 以及凝血酶对肌动球蛋白收缩性的影响
生化/生理作用
(-)-布雷他汀是一种细胞周期抑制剂；非肌肉II型肌球蛋白的选择性抑制剂。
特点和优势
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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