B016
Benoxathian hydrochloride
solid
别名:
2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]-amino]-methyl]-1,4-benzoxathian hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H23NO4S · HCl
化学文摘社编号:
分子量:
397.92
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
产品名称
Benoxathian hydrochloride, solid
InChI
1S/C19H23NO4S.ClH/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14;/h3-9,14,20H,10-13H2,1-2H3;1H
SMILES string
Cl.COc1cccc(OC)c1OCCNCC2CSc3ccccc3O2
InChI key
OWRADFDDJVNMGL-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.)
ethanol: soluble
isopropanol: soluble
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
Biochem/physiol Actions
Selective α1-adrenoceptor antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
S Ma et al.
Journal of neuroendocrinology, 17(1), 22-28 (2005-02-22)
Activation of the brain noradrenergic system during stress plays an important integrative function in coping and stress adaptation by facilitating transmission in many brain regions involved in regulating behavioural and physiological components of the stress response. The medial amygdala (MeA)
Jessica A Cardin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(35), 7745-7753 (2004-09-03)
Norepinephrine (NE) plays a complex role in the behavioral state-dependent regulation of sensory processing. However, the role of forebrain NE action in modulating high-order sensory activity has not been directly addressed. In this study, we take advantage of the discrete
Derek Lupinsky et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(22), 7624-7633 (2010-06-04)
While stressors are known to increase medial prefrontal cortex (PFC) glutamate (GLU) levels, the mechanism(s) subserving this response remain to be elucidated. We used microdialysis and local drug applications to investigate, in male Long-Evans rats, whether the PFC GLU stress
C H Brown et al.
The Journal of physiology, 507 ( Pt 3), 831-842 (1998-05-23)
1. We have tested the hypothesis that morphine withdrawal excitation of oxytocin neurones that follows from administration of naloxone to morphine-dependent rats is a consequence of excitation of noradrenergic neurones. 2. Female rats were made morphine dependent by intracerebroventricular (i.c.v.)
S Ma et al.
Journal of neuroendocrinology, 17(11), 761-769 (2005-10-13)
Chronic intermittent cold stress sensitises activation of the hypothalamic-pituitary-adrenal (HPA) axis by novel acute stress. We have shown that enhanced noradrenergic function in limbic forebrain contributes to HPA sensitisation. In the present study, we investigated whether chronic intermittent cold also
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