产品名称
抗-IGFBP7 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
29 kDa
species reactivity
horse, human, rat, guinea pig, dog, bovine, rabbit
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IGFBP7(3490)
Application
抗-IGFBP7兔抗适用于以1μg/ml的浓度用于western blot应用。
Biochem/physiol Actions
IGFBP7包含1个Ig样C2型（免疫球蛋白样）结构域、1个IGFBP N端结构域和1个Kazal样结构域。它以相对较低的亲和力与IGF-I和IGF-II结合。IGFBP7可刺激前列环素（PGI2）的产生。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
胰岛素样生长因子结合蛋白7（IGFBP7）是一种可与IGF-I紧密结合的蛋白，对IGF-II的亲和力较低。现已确知它能够介导细胞粘附和前列环素的产生。IGFBP7的表达丧失与肿瘤发生相关。
抗-IGFBP7兔抗可识别人、狗、牛、猪、小鼠和兔IGFBP7。
抗-IGFBP7兔抗可识别人、狗、牛、猪、小鼠和兔IGFBP7。
Immunogen
靶向人IGFBP7 C末端区域的合成肽
Other Notes
合成肽位于以下区域内：RGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALH
Physical form
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Valentina Evdokimova et al.
Science signaling, 5(255), ra92-ra92 (2012-12-20)
Insulin-like growth factor-binding protein 7 (IGFBP7) is a secreted factor that suppresses growth, and the abundance of IGFBP7 inversely correlates with tumor progression. Here, we showed that pretreatment of normal and breast cancer cells with IGFBP7 interfered with the activation
Narendra Wajapeyee et al.
Cell, 132(3), 363-374 (2008-02-13)
Expression of an oncogene in a primary cell can, paradoxically, block proliferation by inducing senescence or apoptosis through pathways that remain to be elucidated. Here we perform genome-wide RNA-interference screening to identify 17 genes required for an activated BRAF oncogene
J Darr et al.
Oncogene, 33(23), 3024-3032 (2013-07-16)
SMARCB1 (Snf5/Ini1/Baf47) is a potent tumor suppressor, the loss of which serves as the diagnostic feature in malignant rhabdoid tumors (MRT) and atypical teratoid/rhabdoid tumors (AT/RT), two highly aggressive forms of pediatric neoplasms. SMARCB1 is a core subunit of Swi/Snf
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