Anti-RTN4 (AB2) antibody produced in rabbit

The previously assigned protein identifier Q7L7Q5 has been merged into Q9NQC3. Full details can be found on the UniProt database.

Synthetic peptide directed towards the middle region of human RTN4

Anti-RTN4 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 0.25μg/mL.

RTN4 (reticulon 4) gene is a member of reticulon encoding genes family. It is expressed in oligodendrocytes and predominantly associates with the endoplasmic reticulum. It is a component of CNS white matter that inhibits the axonal regeneration and induces collapse in dorsal root ganglion growth cones. Beta-secretase beta-site APP cleaving enzyme 1 (BACE1), is a membrane-bound aspartyl protease that plays a pivotal role in the generation of amyloid beta-protein (Abeta). RTN4 interacts with BACE1 and blocks its activity.

Synthetic peptide located within the following region: RAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAV

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

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