Anti-LNX1 antibody produced in rabbit

Ligand of numb-protein X 1 (LNX1) is an E3 ubiquitin ligase which contains RING (Really Interesting New Gene) and PDZ (Post-synaptic density, 95 kDa, Discs large, Zona Occludens-1) domains. LNX1 may function as a signaling scaffold protein with a PDZ domain has been shown to bind KCNA4, PAK6, PLEKHG5, PKC-α1, TγK2 and PBK.

Synthetic peptide directed towards the C terminal region of human LNX1

Anti-LNX1 polyclonal antibody is used to tag ligand of numb-protein X 1 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of ligand of numb-protein X 1 as a signaling scaffold and E3 ubiquitin ligase.

Anti-LNX1 polyclonal antibody reacts with bovine, canine, human, mouse, and rat ligand of numb-protein X 1 proteins.

LNX1 is a membrane-bound protein that is involved in signal transduction and protein interactions. LNX1 is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis.This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene.

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Synthetic peptide located within the following region: SHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVA

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