生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
33 kDa
种属反应性
rabbit, guinea pig, bovine, horse, human, dog
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... MEOX2(4223)
免疫原
Synthetic peptide directed towards the C terminal region of human MEOX2
生化/生理作用
MEOX2 is a transcription regulator that is essential for limb myogenesis in vertebrates. It regulates the activity of NF-κB and inhibits the activation of vascular endothelial cells in response to hypoxia and proangiogenic factors. MEOX1 and 2 regulate the activity cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) and induce cell cycle arrest in endothelial cells.
序列
Synthetic peptide located within the following region: REKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Yun Chen et al.
Cardiovascular research, 87(4), 723-731 (2010-04-28)
Tumours secrete proangiogenic factors to induce the ingrowth of blood vessels, the end targets of which are vascular endothelial cells (ECs). The MEOX2 homeoprotein inhibits nuclear factor-kappaB (NF-kappaB) signalling and EC activation in response to serum and proangiogenic factors. We
Susan Reijntjes et al.
The International journal of developmental biology, 51(8), 753-759 (2007-10-17)
We have examined the expression pattern of the avian Meox1 homeobox gene during early development and up to late limb bud stages. Its expression pattern indicates that it is involved in somite specification and differentiation. The domains of expression are
Josette M Douville et al.
PloS one, 6(12), e29099-e29099 (2011-12-30)
Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are essential for determining whether a cell enters
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