推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
43 kDa
种属反应性
mouse, human
浓度
0.5 mg - 1 mg/mL
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... PTRF(19285)
一般描述
Polymerase I and transcript release factor (PTRF) contains a leucine zipper motif, a nuclear localization signal, and PEST domains. It is critically involved in termination of transcription by stalling RNA poly I and releasing it from the elongating transcript. PTRF is also found localized to caveolae and regulates formation of the vesicles at the plasma membrane.
免疫原
Synthetic peptide directed towards the middle region of mouse PTRF
生化/生理作用
In mouse, pausing of elongation complexes is mediated by the transcription termination factor TTF-I bound to the ′Sal box′ terminator downstream of the rDNA transcription unit. PTRF is a Pol I and transcript release factor for dissociation of paused ternary complexes.
序列
Synthetic peptide located within the following region: SEALPEKEGDELGEGERPEDDTAAIELSSDEAVEVEEVIEESRAERIKRS
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Rahul Chadda et al.
Cell, 132(1), 23-24 (2008-01-15)
Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae
Stéphanie Torrino et al.
The Journal of cell biology, 217(12), 4092-4105 (2018-10-24)
Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer tension variations at the plasma membrane. Here we show that under mechanical stress, the EHD2 ATPase is rapidly released from caveolae, SUMOylated, and translocated to the nucleus, where
P Jansa et al.
The EMBO journal, 17(10), 2855-2864 (1998-06-10)
Termination of transcription by RNA polymerase I (Pol I) is a two-step process which involves pausing of elongating transcription complexes and release of both pre-rRNA and Pol I from the template. In mouse, pausing of elongation complexes is mediated by
Vikas A Tillu et al.
Molecular biology of the cell, 26(20), 3561-3569 (2015-08-14)
Caveolae are abundant surface organelles implicated in a range of cellular processes. Two classes of proteins work together to generate caveolae: integral membrane proteins termed caveolins and cytoplasmic coat proteins called cavins. Caveolae respond to membrane stress by releasing cavins
Kerrie-Ann McMahon et al.
eLife, 10 (2021-06-19)
Caveolae-associated protein 3 (cavin3) is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome using genome-edited cells together with label-free quantitative proteomics. These studies revealed a prominent role for cavin3 in DNA repair, with BRCA1 and BRCA1
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