推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
分子量
55 kDa
种属反应性
human
浓度
0.5 mg - 1 mg/mL
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ZIC2(7546)
免疫原
对应人ZIC2 C末端区域的合成肽
生化/生理作用
ZIC2是一种C2H2型锌指蛋白，可作为转录抑制子，调节多巴胺受体D1的组织特异性表达。ZIC2表达对于神经系统发育和神经突起生长比较重要。ZIC2可抑制胚胎发育期间Wnt/β-连环蛋白介导的信号转导。
序列
合成肽位于以下区域内： EPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGS
外形
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Y Zhang et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 25(6), 538-541 (2013-02-19)
From a forward genetic screen in mice we isolated a novel Zic2 allele with abnormal aggregation of meconium in the gastrointestinal tract. Zic2(m1Nisw) mutant embryos show an increase in the number of enteric neurons in vivo and disorganization of the
Zhi-Hua Liu et al.
International journal of cancer, 147(2), 505-518 (2020-02-18)
Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective treatments. Thus, to develop potential
Rasoul Pourebrahim et al.
The Journal of biological chemistry, 286(43), 37732-37740 (2011-09-13)
The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-catenin·TCF4-mediated transcription.
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