推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
分子量
29 kDa
种属反应性
human, rat, guinea pig, mouse
浓度
0.5 mg - 1 mg/mL
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
应用
research pathology
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SNAI1(6615)
一般描述
Snail homolog 1 (Drosophila) (SNAI1), a zinc finger transcription factor, is a transcription repressor that down-regulates the expression of ectodermal genes within the mesoderm. SNAI1 triggers the initiation of epithelial to mesenchymal transition (EMT), a process that provies epithelial cells with mesenchymal features and invasive properties during embryonic development and tumor progression. Consequently, Snai1 plays a major role in tumor growth, cell invasion and metastasis.
特异性
Rabbit polyclonal anti-SNAI1 antibody reacts with human, mouse, and rat Snail homolog 1 proteins.
免疫原
Synthetic peptide directed towards the N terminal of human SNAI1.
应用
Rabbit polyclonal anti-SNAI1 antibody is used to tag Snail homolog 1 (Drosophila)for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of Snail homolog 1 in epithelial to mesenchymal transition (EMT) during embryogenesis and tumor progression.
序列
Synthetic peptide located within the following region: MPRSFLVRKPSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEIL
外形
Lyophilized from PBS buffer with 2% sucrose
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Weidong Zhao et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 36(4), E223-E233 (2013-08-03)
Epithelial-mesenchymal transition (EMT) is crucial for tumor progression and metastasis. Snail family members, including Snail, Slug and Smuc, are the transcription factors that repress E-cadherin expression and induce epithelial-mesenchymal transition in some tumor tissues. In this study, the expression of
Seung-Hyun Jeong et al.
Molecular medicine reports, 14(6), 5148-5154 (2016-10-26)
Hypoxia-induced epithelial-mesenchymal transition (EMT) has been identified as essential for tumor progression and metastasis. The present study examined the effects of an antioxidant, dieckol, on hypoxia‑induced EMT in HT29 human colorectal cancer cells. HT29 cells were treated with a hypoxia‑inducing
Damian Ryszawy et al.
Carcinogenesis, 35(9), 1920-1930 (2014-02-08)
Suppressive function of connexin(Cx)43 in carcinogenesis was recently contested by reports that showed a multifaceted function of Cx43 in cancer progression. These studies did not attempt to model the dynamics of intratumoral heterogeneity involved in the metastatic cascade. An unorthodox
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