Anti-NR5A1 antibody produced in rabbit

NR5A1 (or steroidogenic factor 1) is a nuclear receptor that modulates the transcription of genes involved in the hypothalamic-pituitary-steroidogenic axis. Mutations in NR5A1 have been linked to ovarian insufficiency and congenital adrenal hypoplasia.
Rabbit Anti-NR5A1 antibody recognizes bovine, canine, human, mouse, rat, and pig NR5A1.

Synthetic peptide directed towards the middle region of human NR5A1

Rabbit Anti-NR5A1 antibody can be used for western blot (2.0μg/ml) and immunohistochemistry (4-8μg/ml, using paraffin embedded tissues) assays.

NR5A1 is an important regulator of steroidogeneisis which is present in human skin and its appendages. It plays a role in regulating p450scc expression with TReP-132 and CBP/p300. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Synthetic peptide located within the following region: AVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGP

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

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