生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
48 kDa
种属反应性
mouse, dog, guinea pig, human, rat
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TCF3(6929)
免疫原
Synthetic peptide directed towards the C terminal region of human TCF3
应用
Anti-TCF3 antibody produced in rabbit is suitable for western blotting at a concentration of 5 μg/ml.
生化/生理作用
TCF3 belongs to the E-protein (class I) family of transcription factors and is an important regulator of B and T lymphocyte development, tumor growth and progression. TCF3 modulates the Wnt-mediated signaling and regulates osteogenesis and neural differentiation.
序列
Synthetic peptide located within the following region: EENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPPEQKAEREKERRVAN
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
W Liu et al.
Cell death & disease, 4, e539-e539 (2013-03-16)
Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the
Michal Slyper et al.
Cancer research, 72(21), 5613-5624 (2012-10-24)
Regulatory factors controlling stem cell identity and self-renewal are often active in aggressive cancers and are thought to promote their growth and progression. TCF3 (also known as TCF7L1) is a member of the TCF/LEF transcription factor family that is central
Yaser Atlasi et al.
PLoS genetics, 9(5), e1003424-e1003424 (2013-05-10)
Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli) tumor suppressor gene constitutively activates Wnt signaling in ESCs and
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