推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
47 kDa
种属反应性
human
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SOX8(30812)
一般描述
Sox8 belongs to the SoxE family of transcription factors that are critical for development of neural crest cells. The Sox gene family has been implicated in a number of developmental disorders.
免疫原
Synthetic peptide directed towards the C terminal region of human SOX8
应用
Anti-SOX8 antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml.
生化/生理作用
Sox8 is expressed in Sertoli cells and regulates the spermatogenesis and spermatogenic cycle. Deficiency of Sox8 results in degeneration of adipose tissue and mild osteopenia.
序列
Synthetic peptide located within the following region: ASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGP
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Caroline E Haldin et al.
The international journal of biochemistry & cell biology, 42(3), 441-444 (2009-11-26)
Neural crest cells are the primary innovation that led to evolution of the vertebrates, and transcription factors of the SoxE family (Sox8, Sox9 and Sox10) are among the central players regulating the development of these cells. In all vertebrates examined
Sabine I E Guth et al.
Journal of lipid research, 50(7), 1269-1280 (2009-03-17)
Although the transcription factor Sox8 is broadly expressed during embryogenesis in developing ectodermal and mesodermal tissues, mice develop surprisingly normally in the absence of Sox8. Phenotypes in adult Sox8-deficient mice include mild osteopenia, late-onset male infertility, and reduced weight. We
Moira K O'Bryan et al.
Developmental biology, 316(2), 359-370 (2008-03-18)
Sox8 encodes a high-mobility group transcription factor that is widely expressed during development. Sox8, -9 and -10 form group E of the Sox gene family which has been implicated in several human developmental disorders. In contrast to other SoxE genes
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