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Merck
CN
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文件

A9978

Sigma-Aldrich

阿卡地新

≥98% (HPLC), powder, AMPK activator

别名:

5-氨基咪唑-4-羧酰胺-1-β-D-呋喃甲苷, N1-(β-D-核糖呋喃甲酰)-5-氨基咪唑-4-羧酰胺, 阿卡地新

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About This Item

经验公式（希尔记法）:
C9H14N4O5
CAS号:
2627-69-2
分子量:
258.23
EC 号:
220-097-5
MDL编号:
MFCD00869751
UNSPSC代码:
12352200
PubChem化学物质编号:
24724407
NACRES:
NA.77

product name

阿卡地新, ≥98% (HPLC), powder

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

tan

mp

214-215 °C

溶解性

H2O: >7 mg/mL

运输

dry ice

储存温度

−20°C

SMILES字符串

NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N

InChI

1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1

InChI key

RTRQQBHATOEIAF-UUOKFMHZSA-N

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一般描述

单磷酸腺苷蛋白激酶（AMPK）激活剂5-氨基咪唑-4-羧酰胺核糖核苷酸（AICAR）可调节细胞能量。它可调控脂质和葡萄糖代谢、促炎反应、细胞因子生产、细胞增殖和凋亡。AICAR可改善大鼠的缺血或再灌注损伤和肾脏纤维化。其可提供肾小管坏死保护作用。

应用

AICAR已用于通过JAK（酪氨酸蛋白激酶）/ STAT（信号转导和转录激活子）/ SOCS（细胞因子信号转导抑制剂）途径提供抗顺铂诱导的急性肾脏损伤保护。它还用于检测FapR（丙二酰辅酶A反应性细菌转录因子）-NLuc（纳米荧光素酶）生物传感器的活性。

生化/生理作用

阿卡地新是AMP活化蛋白激酶(AMPK)的细胞渗透性激活剂，是一种代谢主调节因子，在能量利用率降低时被激活(高细胞AMP:ATP比值)，用于抑制合成代谢过程。在体内，药物激活AMPK与AICAR可模拟运动和触发胰岛素无关的骨骼肌葡萄糖摄取。

特点和优势

该化合物是激酶磷酸酶生物学研究的推荐产品。点击此处查看更多特色的激酶磷酸酶生物学产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How can I store a solution of AICAR, Product A9978?

    We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use.  We recommend storing at -20°C in single use aliquots.

  6. What can I use to solubilize AICAR, Product A9978?

    We list the solubility in water on the lot specific Certificate of Analysis.  We typically test the solubility of AICAR in water (7 mg/mL).

  7. What is the appearance of Product A9978, AICAR?

    Product No. A9978, AICAR, is a powder.  The color of the powder will be described on the lot specific Certificate of Analysis.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Hiroaki Sunaga et al.
Scientific reports, 9(1), 11841-11841 (2019-08-16)
Fibroblast growth factor 21 (FGF21) is a metabolic hormone having anti-oxidative and anti-hypertrophic effects. However, the regulation of FGF21 expression during acute myocardial infarction (AMI) remains unclear. We tested blood samples from 50 patients with AMI and 43 patients with
Ai Ushiyama et al.
Biology of reproduction, 100(6), 1482-1491 (2019-02-06)
Despite knowledge that glucose metabolism is essential for the regulation of signaling cascades in the sperm that are pre-assembled into specific areas and function at multistage for fertilization, the physiological roles of glucose in avian sperm are poorly understood. Accumulated
AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway
Tsogbadrakh B, et al.
Biochemical and Biophysical Research Communications (2019)
Genetically-encoded FapR-NLuc as a biosensor to determine malonyl-CoA in situ at subcellular scales
Du Y, et al.
Bioconjugate Chemistry (2019)
Hongshun Wang et al.
Cell death & disease, 10(9), 627-627 (2019-08-21)
Oxysterol-binding protein like 2 (OSBPL2) was identified as a novel causal gene for autosomal dominant nonsyndromic hearing loss. However, the pathogenesis of OSBPL2 deficits in ADNSHL was still unclear. The function of OSBPL2 as a lipid-sensing regulator in multiple cellular
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