A9546
2-氨基-6-甲基巯基嘌呤
≥95%
别名:
2-氨基-6-甲基硫嘌呤
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关于此项目
经验公式（希尔记法）:
C6H7N5S
化学文摘社编号:
分子量:
181.22
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
214-833-4
MDL number:
Assay:
≥95%
Form:
solid
InChI key
YEGKYFQLKYGHAR-UHFFFAOYSA-N
InChI
1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
SMILES string
[H]n1cnc2c(SC)nc(N)nc12
assay
≥95%
form
solid
Quality Level
Application
2-氨基-6-甲基巯基嘌呤是一种2-氨基-6-烷基二硫代嘌呤，已与其他6位碳类似物一起用于研究大脑特异性地西泮的结合。
2-氨基-6-甲基巯基嘌呤（6-MTG）已用作Dulbecco′s改良的Eagles培养基（DMEM）培养基的补充剂，用于选择表达GPT的重组病毒mCMVhMIEPE-gpt.lacZ（巨细胞病毒主要立即早期启动子-增强子复合物-gpt.lacz）。它也已用作高效液相色谱（HPLC）中的标准品，以评估巯嘌呤甲基转移酶（TPMT）酶的活性。
Biochem/physiol Actions
2-氨基-6-甲基巯基嘌呤是由6-巯基嘌呤通过硫嘌呤甲基转移酶（TMPT）酶的S甲基化活性合成的。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
S C Sung et al.
Biochemical pharmacology, 33(11), 1737-1739 (1984-06-01)
Various derivatives of 2-amino-6- methylthiopurine with substituents at the 6-position of purine were tested for their abilities to displace [3H]diazepam binding to rat brain membranes. The potency was dependent on the carbon chain-length in the 6-position of purine. Among the
Effect of 9-alkyl derivatives of 6-methylthioguanine on brain specific binding of [3H]diazepam.
S C Sung et al.
Biochemical pharmacology, 35(20), 3645-3646 (1986-10-15)
A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease
Bahrehmand F, et al.
Acta Medica Iranica, 55(6), 360-367 (2017)
In vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirus
Grzimek NKA, et al.
Journal of Virology, 73(6), 5043-5055 (1999)
G R Erdmann et al.
Biomedical chromatography : BMC, 4(2), 47-51 (1990-03-01)
A reversed phase high performance liquid chromatographic procedure was developed to quantify 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in red blood cells. The free base of each thiopurine was liberated from the respective nucleoside and nucleotide moiety by acid hydrolysis, which
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