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应用
2-氨基-6-甲基巯基嘌呤是一种2-氨基-6-烷基二硫代嘌呤，已与其他6位碳类似物一起用于研究大脑特异性地西泮的结合。
2-氨基-6-甲基巯基嘌呤（6-MTG）已用作Dulbecco′s改良的Eagles培养基（DMEM）培养基的补充剂，用于选择表达GPT的重组病毒mCMVhMIEPE-gpt.lacZ（巨细胞病毒主要立即早期启动子-增强子复合物-gpt.lacz）。它也已用作高效液相色谱（HPLC）中的标准品，以评估巯嘌呤甲基转移酶（TPMT）酶的活性。
生化/生理作用
2-氨基-6-甲基巯基嘌呤是由6-巯基嘌呤通过硫嘌呤甲基转移酶（TMPT）酶的S甲基化活性合成的。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
S C Sung et al.
European journal of pharmacology, 81(3), 505-508 (1982-07-16)
We have compared fifteen synthetic purines and purine nucleosides on their ability to displace [3H]diazepam binding to rat brain membranes. Among these analogs, 6-methylthioguanine was found to be most potent, inhibiting competitively the specific binding of [3H]diazepam with a Ki
K Rowland et al.
Journal of chromatography. B, Biomedical sciences and applications, 705(1), 29-37 (1998-03-14)
This paper describes a specific and sensitive reversed-phase HPLC assay for the measurement of 6-methylthioguanine (methyl-TG) and methyl-TG nucleotides (methyl-TGNs) in red blood cells (RBCs), which is suitable for routine clinical use. Briefly, an ethyl acetate extract of RBCs is
In vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirus
Grzimek NKA, et al.
Journal of Virology, 73(6), 5043-5055 (1999)
G R Erdmann et al.
Biomedical chromatography : BMC, 4(2), 47-51 (1990-03-01)
A reversed phase high performance liquid chromatographic procedure was developed to quantify 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in red blood cells. The free base of each thiopurine was liberated from the respective nucleoside and nucleotide moiety by acid hydrolysis, which
Effect of 9-alkyl derivatives of 6-methylthioguanine on brain specific binding of [3H]diazepam.
S C Sung et al.
Biochemical pharmacology, 35(20), 3645-3646 (1986-10-15)
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