生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
fractionated antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
human
包装
vial of 2 mL lyophilized antiserum
技术
indirect ELISA: 1:25,000
UniProt登记号
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... SERPINC1(462)
一般描述
Antithrombin III (ATIII) is a small glycoprotein produced by the liver that functions as a serine protease inhibitor to block coagulation.
Antithrombin III is a 58kDa glycoprotein synthesized in the liver. It has two domains, a heparin-binding domain and target protease binding domain.
免疫原
human antithrombin III
应用
Anti-Antithrombin III antibody has been used in western blotting and antigenic assay.
生化/生理作用
Antithrombin III is a serine protease inhibitor which affects many intrinsic and extrinsic blood coagulation pathways. It inactivates the function of thrombin and factor X in blood. Severe sepsis is caused due to lack of antithrombin III.
外形
由 0.01M 的磷酸缓冲盐溶液 (pH 7.2) 冻干
重悬
Reconstitute with 2 mL deionized water.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.
Weitz J I, et al.
The Journal of Clinical Investigation, 86(2), 385-391 (1990)
Carlos Bravo-Pérez et al.
JCI insight, 7(19) (2022-10-11)
Antithrombin, a major endogenous anticoagulant, is a serine protease inhibitor (serpin). We characterized the biological and clinical impact of variants involving C-terminal antithrombin. We performed comprehensive molecular, cellular, and clinical characterization of patients with C-terminal antithrombin variants from a cohort
María Eugenia de la Morena-Barrio et al.
Frontiers in cardiovascular medicine, 9, 887664-887664 (2022-08-09)
Aortic valve replacement is the gold standard treatment for severe symptomatic aortic stenosis, but thrombosis of bioprosthetic valves (PVT) remains a concern. To analyze the factors involved in the contact pathway during aortic valve replacement and to assess their impact
Defects of splicing in antithrombin deficiency
de la Morena-Barrio M E, et al.
Research and practice in thrombosis and haemostasis, 1(2), 216-222 (2017)
Mara Toderici et al.
PloS one, 11(3), e0152159-e0152159 (2016-03-24)
Antithrombin is a crucial anticoagulant serpin whose even moderate deficiency significantly increases the risk of thrombosis. Most cases with antithrombin deficiency carried genetic defects affecting exons or flanking regions of SERPINC1.We aimed to identify regulatory mutations inSERPINC1 through sequencing the
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