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A9451

马兜铃酸I 钠盐

Name: 马兜铃酸I 钠盐
Brand: SIGMA

powder, ≥97%

别名:

马兜铃酸钠盐

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₀NNaO₇

化学文摘社编号:

10190-99-5

分子量:

363.25

NACRES:

NA.77

PubChem Substance ID:

24891454

UNSPSC Code:

12352202

EC Number:

233-463-4

MDL number:

MFCD00210760

Assay:

≥97%

Form:

powder

Solubility:

H₂O: 50 mg/mL

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属性

Quality Level

200

assay

≥97%

form

powder

solubility

H₂O: 50 mg/mL

SMILES string

[Na+].COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C([O-])=O

InChI

1S/C17H11NO7.Na/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13;/h2-6H,7H2,1H3,(H,19,20);/q;+1/p-1

InChI key

BQVOPWJSBBMGBR-UHFFFAOYSA-M

说明

Biochem/physiol Actions

是一些中草药的成分，并负责其肾毒性。是一种前药，通过将硝基还原成胺而活化，其形成细胞毒性 DNA 加合物。

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301 + H311 + H331,H351

pcodes

P202 - P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma.

Huan Lu et al.

Theranostics, 10(10), 4323-4333 (2020-04-16)

Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy and subsequent upper tract urothelial carcinoma (UTUC). East Asian populations, who have a high prevalence of UTUC, have an unusual genome-wide AA-induced

Novel kidney dissociation protocol and image-based flow cytometry facilitate improved analysis of injured proximal tubules.

Marika Manolopoulou et al.

American journal of physiology. Renal physiology, 316(5), F847-F855 (2019-02-14)

Flow cytometry studies on injured kidney tubules are complicated by the low yield of nucleated single cells. Furthermore, cell-specific responses such as cell cycle dynamics in vivo have conventionally relied on indirect immunohistochemistry and proximal tubule markers that may be

Cyclophilin D Promotes Acute, but Not Chronic, Kidney Injury in a Mouse Model of Aristolochic Acid Toxicity.

Khai Gene Leong et al.

Toxins, 13(10) (2021-10-23)

The plant-derived toxin, aristolochic acid (AA), is the cause of Chinese Herb Nephropathy and Balkan Nephropathy. Ingestion of high dose AA induces acute kidney injury, while chronic low dose ingestion leads to progressive kidney disease. Ingested AA is taken up

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全球贸易项目编号

货号	GTIN
A9451-50MG	04061833616499
A9451-250MG	04061833616482