所有图片(1)
About This Item
经验公式（希尔记法）:
C16H26O5
CAS号:
分子量:
298.37
MDL编号:
UNSPSC代码:
51101908
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D +155 to +175°, c = 0.5 in methanol
颜色
off-white to light brown
溶解性
DMSO: ≥20 mg/mL
创始人
Novartis
储存温度
room temp
SMILES字符串
CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3
InChI
1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChI key
SXYIRMFQILZOAM-HVNFFKDJSA-N
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一般描述
青蒿素 (ART) 是一种存在于传统中草药青蒿中的天然化合物。
应用
蒿甲醚已被用于：
- 作为抗血吸虫化合物测试其对幼虫期曼氏血吸虫的作用
- 提高小鼠胚胎成纤维细胞 (MEF) 和人骨肉瘤HT1080 细胞对半胱氨酸饥饿 (STV) 引起的铁死亡的敏感性
- 刺激胰岛及其对α到β分化转移的作用
生化/生理作用
蒿甲醚是青蒿素的一种甲醚衍生物。它可用于治疗疟疾寄生虫恶性疟原虫的多重耐药菌株，并显示出治疗血吸虫病的潜力。
青蒿素含有具备高反应活性的内过氧化合物桥，这种桥结构是其治疗潜力的核心。内过氧化合物键与疟原虫红细胞中的铁反应。 这导致产生直接靶向疟原虫的活性氧（ROS）。 青蒿素还可调节肿瘤细胞中的铁死亡。α蒿甲醚可减少细胞转录因子Arx 的表达。初生胰岛的长期暴露还会导致难以鉴定内分泌细胞类型及其功能。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Org. Perox. D
储存分类代码
5.2 - Organic peroxides and self-reacting hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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