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Merck
CN
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文件

安全信息

A9106

Sigma-Aldrich

ADP-核糖环化酶

1000-3000 units/mg protein

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别名:
腺苷二磷酸核糖环化酶 来源于加州海兔
CAS号:
135622-82-1
MDL编号:
MFCD00212894
UNSPSC代码:
12352204
NACRES:
NA.54

形式

lyophilized powder

质量水平

200

比活

1000-3000 units/mg protein

组成

Protein, ≤10%

包装

vial of ≥80 μg protein

储存温度

−20°C

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应用

ADP-核糖基环化酶是Ca2+信号传递的一种第二信使。 它可用于研究钙信号转导并已被用于研究吗啡的抗伤害作用和耐受性。

生化/生理作用

ADP-核糖基环化酶是一种可将NAD环化为cADPR的细胞内钙调节剂。大脑中绝大多数的ADP-核糖基环化酶活性都被认为与CD38相关。 烟酰胺是一种已知的CD38 ADP-核糖基环化酶活性抑制剂。

单位定义

在 pH 7.0、25°C 下，一单位可在5分钟内从β-NAD+产生1 μmole的环状ADP核糖。

外形

冻干粉，含海藻糖、磷酸钾以及二硫苏糖醇

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H334

预防措施声明

P261 - P284 - P501

危险分类

Resp. Sens. 1

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品

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Heather S Loring et al.
Biochemistry, 59(8), 933-942 (2020-02-13)
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents degeneration, thereby demonstrating that SARM1
Lynn C Hull et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1042-1050 (2010-06-17)
Our previous studies have demonstrated that an increase in intracellular levels of Ca(2+) in neurons is an important component of both the antinociception produced by morphine and morphine's tolerance. The present study tested the hypothesis that the Ca(2+) signaling second
H C Lee et al.
Cell regulation, 2(3), 203-209 (1991-03-01)
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin
Xiaojian Shao et al.
Nature protocols, 15(9), 2813-2836 (2020-08-05)
Several noncanonical initial nucleotides (NCINs) have been found to cap RNAs and possibly regulate RNA stability, transcription and translation. NAD+ is one of the NCINs that has recently been discovered to cap RNAs in a wide range of species. Identification
Nicholas D Peterson et al.
eLife, 11 (2022-02-01)
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress - a process known as phase transition. Here, we show that a phase transition of the Caenorhabditis elegans Toll/interleukin-1 receptor domain protein
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