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安全信息

A9024

Sigma-Aldrich

α1-抗胰蛋白酶 来源于人类血浆

salt-free, lyophilized powder

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别名:
α1-蛋白酶抑制剂
CAS号:
9041-92-3
EC 号:
232-924-7
MDL编号:
MFCD00130469
UNSPSC代码:
12352202
NACRES:
NA.77

生物来源

human plasma

质量水平

200

检测方案

≥70% protein basis (biuret)

形式

salt-free, lyophilized powder

UniProt登记号

P01009
P08246

储存温度

2-8°C

基因信息

human ... ELA2(1991) , SERPINA1(5265)

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生化/生理作用

丝氨酸蛋白酶抑制剂；抑制胰蛋白酶、胰凝乳蛋白酶和胰腺和粒细胞弹性蛋白酶、以及顶体酶。有效浓度与蛋白酶等摩尔。遗传性 α1-抗胰蛋白酶缺乏的影响和某些自身免疫状态是由体内不受控制的蛋白水解引起的。Direct α1-抗胰蛋白酶替代疗法在1型糖尿病的动物模型中具有应用前景。
1-4mg可抑制1.0mg胰蛋白酶（每mg蛋白大约10,000 BAEE单位活性）。1-6mg可抑制1.0mg α-胰凝乳蛋白酶（每mg蛋白>=40 BTEE单位活性）。

注意

含有0.01％NaN3的水溶液可稳定几个月。溶液可在−80 °C下储存，但不应重新冷冻。其在pH 5.5以下不稳定。其可由一些非丝氨酸蛋白酶，以及氧化活性位点的甲硫氨酸残基进行灭活。

制备说明

经色谱法制备和部分纯化。

免责声明

仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the carbohydrate content of human alpha-1-Antitrypsin?

    We have found the information on alpha-1-antitrypsin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.The alpha-1-antitrypsin is 12 percent carbohydrate, citing K. Heide and H.G. Schwick, Chemistry and Significance of the Carbohydrate Moieties of Human Serum Glycoproteins, Angew. Chem., Int. Ed. Eng., 12, 721-733 (1973).The table also gives information on the percentage of each type of monosaccharide that is present.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Roy B Lefkowitz et al.
Analytical chemistry, 82(19), 8251-8258 (2010-09-11)
The ability to measure protease activity in the blood is important for the development of future diagnostics and for biomedical research. Presently, protease assays require sample preparation, making them time-consuming, costly, less accurate, and unsuitable for point-of-care (POC) diagnostics. Recently
O I Aruoma et al.
FEBS letters, 244(1), 76-80 (1989-02-13)
The elastase-inhibitory activity of alpha 1-antiproteinase is inactivated by hydroxyl radicals (.OH) generated by pulse radiolysis or by reaction of iron ions with H2O2 in the presence of superoxide or ascorbate. Uric acid did not protect alpha 1-antiproteinase against inactivation
O I Aruoma et al.
The Biochemical journal, 256(1), 251-255 (1988-11-15)
It has been suggested that taurine, hypotaurine and their metabolic precursors (cysteic acid, cysteamine and cysteinesulphinic acid) might act as antioxidants in vivo. The rates of their reactions with the biologically important oxidants hydroxyl radical (.OH), superoxide radical (O2.-), hydrogen
B Halliwell et al.
FEBS letters, 213(1), 15-17 (1987-03-09)
Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint
M Wasil et al.
The Biochemical journal, 243(3), 867-870 (1987-05-01)
Thiourea and dimethylthiourea are powerful scavengers of hydroxyl radicals (.OH), and dimethylthiourea has been used to test the involvement of .OH in several animal models of human disease. It is shown that both thiourea and dimethylthiourea are scavengers of HOCl
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