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检测方案
≥97% (HPLC)
质量水平
形式
powder
溶解性
water: 19.60-20.40 mg/mL, clear, colorless
储存温度
room temp
SMILES字符串
Br.C[N](C)(CC=C)c1ccc(CCC(=O)CCc2ccc(cc2)[N](C)(C)CC=C)cc1
InChI
1S/C27H38N2O.BrH/c1-7-21-28(3,4)25-15-9-23(10-16-25)13-19-27(30)20-14-24-11-17-26(18-12-24)29(5,6)22-8-2;/h7-12,15-18H,1-2,13-14,19-22H2,3-6H3;1H
InChI key
XBXRQUYORADPMX-UHFFFAOYSA-N
基因信息
human ... ACHE(43)
生化/生理作用
Selective acetylcholinesterase inhibitor.
特点和优势
This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Danger
危险分类
Acute Tox. 2 Oral
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
V P Chen et al.
International journal of obesity (2005), 41(9), 1413-1419 (2017-05-23)
Ghrelin is the only orexigenic hormone known to stimulate food intake and promote obesity and insulin resistance. We recently showed that plasma ghrelin is controlled by butyrylcholinesterase (BChE), which has a strong impact on feeding and weight gain. BChE knockout
Andrea R Durrant et al.
Frontiers in molecular neuroscience, 5, 73-73 (2012-06-23)
The cholinesterases, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) (pseudocholinesterase), are abundant in the nervous system and in other tissues. The role of AChE in terminating transmitter action in the peripheral and central nervous system is well understood. However, both knowledge of
Silvia Olivera-Bravo et al.
British journal of pharmacology, 144(1), 88-97 (2005-01-13)
This work was aimed to determine if 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide (BW284c51), the most selective acetylcholinesterase inhibitor (AchEI), affects the nicotinic acetylcholine (Ach) receptor (AchR) function. Purified Torpedo nicotinic AchRs were injected into Xenopus laevis oocytes and BW284c51 effects on Ach- and
Kevin B Temeyer et al.
Veterinary parasitology, 172(1-2), 114-121 (2010-05-11)
Rhipicephalus (Boophilus) microplus cDNAs, BmAChE1, BmAChE2, and BmAChE3, were previously identified as presumptively encoding acetylcholinesterases (AChEs), but biochemical identity was confirmed only for recombinant BmAChE3. In the present study, four recombinant BmAChE1 constructs and single recombinant constructs of BmAChE2 and
Marcia D Howard et al.
Toxicology, 238(2-3), 157-165 (2007-07-24)
Organophosphorus (OP) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (AChE), the enzyme responsible for inactivating acetylcholine (ACh) at cholinergic synapses. A number of OP toxicants have also been reported to interact directly with muscarinic receptors, in particular the M(2) muscarinic
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