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质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to off-white
溶解性
DMSO: ≥10 mg/mL
储存温度
−20°C
SMILES字符串
Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC
InChI
1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H
InChI key
BRJJFBHTDVWTCJ-UHFFFAOYSA-N
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应用
己联双辛胍二盐酸盐已：
- 用作一种防腐剂，研究其在唾液微生物膜中的抗菌活性
- 用作一种定位于线粒体1 (PTPMT1)特异性抑制剂的蛋白酪氨酸磷酸酶，以研究其对CD8+ T细胞剩余呼吸能力和活力的影响
- 用作PTPMT1抑制剂，研究其在人巨细胞病毒(HCMV)感染的人包皮成纤维细胞(HFF)中复制的抗病毒作用
生化/生理作用
己联双辛胍二盐酸盐是一种双胍化合物。它已经被用于头颈癌的治疗。己联双辛胍二盐酸盐对几种真菌也表现出抗菌膜和抗真菌活性。由于其抗癌活性，可引起哺乳动物细胞线粒体凋亡。己联双辛胍二盐酸盐是口腔消毒剂和隐形眼镜溶液的组分。
己联双辛胍二盐酸盐是一种有效的选择性PTPMT1（线粒体蛋白酪氨酸磷酸酶1）抑制剂。己联双辛胍能够增加离体大鼠胰岛的胰岛素分泌。
特点和优势
《受体分类和信号转导》手册的 磷蛋白磷酸酶（酪氨酸） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zeinab Mamouei et al.
mSphere, 3(5) (2018-11-02)
Invasive fungal infections due to Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans constitute a substantial threat to hospitalized immunocompromised patients. Further, the presence of drug-recalcitrant biofilms on medical devices and emergence of drug-resistant fungi, such as Candida auris, introduce treatment
Allison Campolo et al.
Pathogens (Basel, Switzerland), 10(2) (2021-01-31)
Acanthamoeba keratitis (AK) is a serious ocular infection caused by a ubiquitous free-living amoeba, Acanthamoeba. This infection often results in extensive corneal damage and blindness, and is notoriously difficult to cure. While Acanthamoeba is an abundant organism, AK is most
Mateja Zorko et al.
The Journal of antimicrobial chemotherapy, 62(4), 730-737 (2008-07-19)
Many antibiotics used to treat infections cause release of immunostimulatory cell wall components from bacteria. Therefore, a combination of antimicrobial and endotoxin-neutralizing activity is desired to prevent inflammation induced by destroyed bacteria. Chlorhexidine and alexidine are amphipathic bisbiguanides and could
J Moran et al.
Journal of periodontology, 55(5), 278-282 (1984-05-01)
The phenomenon of surface adsorption appears fundamental to the antiplaque activity of the cationic antiseptics. Moreover, reaction with chromogenic material is relevant to the local side effect of staining. The purpose of this investigation was to determine how such local
M Addy et al.
Journal of clinical periodontology, 8(3), 220-230 (1981-06-01)
A blind cross-over trial was carried out to compare the tooth and tongue staining associated with the use of a 0.035% alexidine and a 0.2% chlorhexidine mouthrinse. Twenty-two volunteers were divided into two groups termed "tea drinkers" and "non-tea drinkers".
商品
Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
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