产品名称
抗-β-淀粉样蛋白 (13-28) 抗体，小鼠单克隆, clone BAM90.1, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BAM90.1, monoclonal
form
buffered aqueous solution
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
enzyme immunoassay: 0.2-0.4 μg/mL using amyloid β-protein
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
Application
小鼠抗-β-淀粉样蛋白（13-28）单克隆抗体可用于免疫印迹分析（1:5,000 的稀释度）。该抗体还可用于IHC、免疫沉淀、荧光红外光谱和酶免疫测定（02-0.4μg/ml）。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
免疫组织化学（1篇论文）
免疫组织化学（1篇论文）
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
General description
β-淀粉样蛋白前体蛋白 (APP) 是由蛋白水解酶β-分泌酶 (BACE1) 和 γ-分泌酶依次裂解，生成以Aβ1-42和 Aβ1-40型为主的β-淀粉样蛋白 (Aβ) 肽。分泌的Aβ肽通过再吸收机制和之后的内体降解过程降解，或通过胞外胰岛素降解酶降解。Aβ的胞外积累导致聚集体和原纤维的形成，最终形成淀粉样蛋白沉着物神经炎斑，其是阿尔茨海默病 (AD) 的标志物。
抗 β-淀粉样蛋白 [13-28] 单克隆抗体可识别β-淀粉样蛋白肽。抗体表位位于氨基酸 20-23 内。
抗 β-淀粉样蛋白 [13-28] 单克隆抗体可识别β-淀粉样蛋白肽。抗体表位位于氨基酸 20-23 内。
淀粉样蛋白是由错误折叠的蛋白质和多肽组成的不溶性蛋白聚集体。淀粉样蛋白沉积与多种神经退行性疾病有关。
Physical form
在 0.01 M 磷酸盐缓冲盐水（pH 7.4）中过滤的溶液。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
常规特殊物品
此项目有
Amyloid-beta-secondary structure distribution in cerebrospinal fluid and blood measured by an immuno-infrared-sensor: A biomarker candidate for Alzheimer?s disease
Nabers A, et al.
Analytical Chemistry, 88, 2755-2762 (2016)
Andreas Nabers et al.
EMBO molecular medicine, 10(5) (2018-04-08)
Alzheimer's disease (AD) is currently incurable, but there is general agreement that a minimally invasive blood biomarker for screening in preclinical stages would be crucial for future therapy. Diagnostic tools for detection of AD are either invasive like cerebrospinal fluid
Julia Stockmann et al.
Alzheimer's research & therapy, 12(1), 169-169 (2020-12-29)
We evaluated Aβ misfolding in combination with Aβ42/40 ratio as a prognostic tool for future clinical progression to mild cognitive impairment (MCI) or dementia due to Alzheimer's disease (AD) in individuals with subjective cognitive decline (SCD). Baseline plasma samples (n = 203)
Interactions of pathological hallmark proteins: Tubulin polymerization promoting protein/p25, beta-amyloid and alpha-synuclein
Olah J, et al.
The Journal of Biological Chemistry, jbc-M111 (2011)
Andreas Nabers et al.
Alzheimer's & dementia (Amsterdam, Netherlands), 11, 257-263 (2019-03-27)
Alzheimer's disease (AD) diagnosis requires invasive CSF analysis or expensive brain imaging. Therefore, a minimal-invasive reliable and cost-effective blood test is requested to power large clinical AD trials at reduced screening failure. We applied an immuno-infrared sensor to measure the
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持