推荐产品
检测方案
≥98% (TLC)
形式
powder
颜色
off-white
溶解性
H2O: 50 mg/mL
SMILES字符串
Cl[H].CC(C)NCC(O)COc1ccccc1CC=C
InChI
1S/C15H23NO2.ClH/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3;/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3;1H
InChI key
RRCPAXJDDNWJBI-UHFFFAOYSA-N
基因信息
human ... ADRB1(153) , ADRB2(154)
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应用
Alprenolol is a nonselective β-blocker and a serotonin 5HT1A receptor antagonist.
生化/生理作用
β1- and β2-adrenoceptor antagonist.
A J Surman et al.
Journal of cardiovascular pharmacology, 21(1), 35-39 (1993-01-01)
We studied the effects of alprenolol and bromoacetylalprenololmenthane (BAAM) on rat left atria. Alprenolol and BAAM at 10(-7), 3 x 10(-7), and 10(-6) M inhibited the cardiac stimulation response slightly, which is indicative of membrane-stabilizing activity independent of beta-adrenoceptor blockade.
Marjukka Ikonen et al.
Colloids and surfaces. B, Biointerfaces, 78(2), 275-282 (2010-04-20)
In this work, isothermal titration calorimetry (ITC) combined with zeta potential measurements was used to study the binding and partitioning of three beta-blockers, alprenolol, labetalol and propranolol, and the local anaesthetic tetracaine into liposomes. The thermodynamic parameters of enthalpy, entropy
Noel Dew et al.
Colloids and surfaces. B, Biointerfaces, 89, 53-60 (2011-10-01)
To fully utilize the extended contact time of gel formulations a novel formulation with drug containing catanionic aggregates offering prolonged drug release and skin penetration were investigated. This study aimed to further explore the drug release process from catanionic vesicles
(-)Alprenolol potentiates the disrupting effects of dizocilpine on sensorimotor function in the rat.
J Zhang et al.
Psychopharmacology, 132(3), 281-288 (1997-08-01)
The beta-adrenoceptor antagonist as well as serotonin 5-HT1 receptor antagonist, (-)alprenolol, was found to potentiate the disrupting effect of the noncompetitive NMDA receptor antagonist, dizocilpine, on prepulse inhibition (PPI) of the acoustic startle response (ASR) in the rat. The facilitating
Y Shirayama et al.
European journal of pharmacology, 331(2-3), 319-323 (1997-07-23)
Desipramine, imipramine, clomipramine, (-)-propranolol, (-)-alprenolol, (+/-)-pentazocine and risperidone caused a concentration-dependent inhibition of 6 nM [3H]DTG (1,3-di-o-tolylguanidine)-defined sigma (sigma) binding with Ki values of about 0.5-2.5 microM in well-washed homogenates obtained from rat cerebral cortex. The saturation studies revealed that
Chromatograms
application for HPLCapplication for HPLC我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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