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The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

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A8423

Sigma-Aldrich

盐酸胺碘酮 盐酸盐

≥98% (TLC), powder, ion channel blocker

别名:

2-丁基-3-苯并呋喃基-4-[2-（二乙氨基）乙氧基]-3,5-二碘苯基酮 盐酸盐, （2-丁基-3-苯并呋喃基） [4-[2-（二乙氨基）乙氧基]-3,5-二碘苯基] 甲酮 盐酸盐

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15 G
¥6,072.73

¥6,072.73

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15 G
¥6,072.73

About This Item

经验公式（希尔记法）:
C25H29I2NO3 · HCl
CAS号:
19774-82-4
分子量:
681.77
EC 号:
243-293-2
MDL编号:
MFCD00069204
UNSPSC代码:
12352200
PubChem化学物质编号:
24277818
NACRES:
NA.77

¥6,072.73

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产品名称

盐酸胺碘酮 盐酸盐, ≥98%

质量水平

200

方案

≥98%

表单

powder

创始人

Wyeth

储存温度

2-8°C

SMILES字符串

C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl

InChI

1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

InChI key

ITPDYQOUSLNIHG-UHFFFAOYSA-N

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此商品
118151188711809
Coated GC Packing phase SP®-1000, 0.1%, matrix 80/100 Carbopack C support, bottle of 15 g

11820

Coated GC Packing

Supelco

11815

Coated GC Packing

Coated GC Packing phase 4% Carbowax 20M + 0.8% KOH, matrix 60/80 Carbopack B support, bottle of 15 g

11887

Coated GC Packing

Coated GC Packing phase 1% SP®-1510, matrix 60/80 Carbopack B support, bottle of 15 g

11809

Coated GC Packing

matrix active group

SP®-1000 phase, 0.1%

matrix active group

SP®-1000 phase, 1%

matrix active group

4% Carbowax 20M + 0.8% KOH phase

matrix active group

1% SP®-1510 phase

parameter

60-225 °C temp. range

parameter

60-225 °C temp. range

parameter

60-220 °C temp. range

parameter

60-230 °C temp. range

compatibility

for analyte group phenols

compatibility

for analyte group halogenated organics

compatibility

for analyte group amines

compatibility

for analyte group Industrial solvents

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

column type

packed GC

column type

packed GC

column type

packed GC

column type

packed GC

packaging

bottle of 15 g

packaging

bottle of 15 g

packaging

bottle of 15 g

packaging

bottle of 15 g

应用

盐酸胺碘酮是一种非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中，随后发生线粒体断裂和细胞死亡。 盐酸胺碘酮可用于废水处理厂废水中甲状腺破坏物质浓度测量研究。
盐酸胺碘酮用于研究其与半胱胺的相互作用，刺激培养的生物传感器细胞系发生自噬。[1]也用于幼虫和成虫器官毒性基因组学筛选，分析药物的转录作用。[2]

生化/生理作用

非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中，随后发生线粒体断裂和细胞死亡。

特点和优势

该化合物由 Wyeth 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。

底物

CYP2C8/9 和 CYP3A 家族（次要通路）抑制剂和底物；CYP2D6、CYP3A 家族、CYP2D6、CYP2A6、CYP2B6 去乙基形式抑制剂

警示用语：

Warning

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Lact. - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000311659
    0000376663
    0000376665
    0000376666
    0000356717

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    1. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    2. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    3. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    4. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    5. What is the solubility of Product A8423, Amiodarone hydrochloride, and in which solvents may it be reconstituted?

      Sigma-Aldrich tests the solubility of Product A8423, Amiodarone hydrochloride in water at a concentration of 50 mg/ml. This requires heating at 105 °C for 10 minutes. This concentration is above the solubility maximum at room temperature. As per the chemicals encyclopedia published by the Royal Society of Chemistry 13th Ed., Entry #482, solubility at 25 °C, (g/100mL):  Water (0.07), Ethanol (1.28), Methanol (9.98), Chloroform (44.51), Methylene Chloride (19.2), and Hexane (0.03).Reportedly, the solubility of the product is 10 mg/ml each in DMSO and in dimethylformamide.

    6. My question is not addressed here, how can I contact Technical Service for assistance?

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