A8423
盐酸胺碘酮 盐酸盐
≥98% (TLC), powder, ion channel blocker
别名:
2-丁基-3-苯并呋喃基-4-[2-（二乙氨基）乙氧基]-3,5-二碘苯基酮 盐酸盐, （2-丁基-3-苯并呋喃基） [4-[2-（二乙氨基）乙氧基]-3,5-二碘苯基] 甲酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C25H29I2NO3 · HCl
化学文摘社编号:
分子量:
681.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
243-293-2
MDL number:
产品名称
盐酸胺碘酮 盐酸盐, ≥98%
Quality Level
assay
≥98%
form
powder
originator
Wyeth
storage temp.
2-8°C
SMILES string
C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl
InChI
1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
InChI key
ITPDYQOUSLNIHG-UHFFFAOYSA-N
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General description
CYP2C8/9 和 CYP3A 家族（次要通路）抑制剂和底物；CYP2D6、CYP3A 家族、CYP2D6、CYP2A6、CYP2B6 去乙基形式抑制剂
Application
盐酸胺碘酮用于研究其与半胱胺的相互作用，刺激培养的生物传感器细胞系发生自噬。也用于幼虫和成虫器官毒性基因组学筛选，分析药物的转录作用。
盐酸胺碘酮是一种非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中，随后发生线粒体断裂和细胞死亡。 盐酸胺碘酮可用于废水处理厂废水中甲状腺破坏物质浓度测量研究。
Biochem/physiol Actions
非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中，随后发生线粒体断裂和细胞死亡。
signalword
Warning
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Lact. - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Journal of environmental sciences (China), 23(4), 671-675 (2011-07-29)
It is generally known that there are many endocrine disrupting compounds (EDCs) in the effluents from wastewater treatment plants (WWTPs). Most research has focused on the occurrence of estrogenic or androgenic activities, while ignoring that there are environmental chemicals disrupting
Editor?s Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models
Poon K, et al.
Toxicological Sciences, 156(1), 133-148 (2017)
Alex Dexter et al.
Analytical and bioanalytical chemistry, 411(30), 8023-8032 (2019-11-30)
Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry imaging strategy, involving repeated analysis of tissue sections by
Aateka Patel et al.
Pharmaceutics, 11(7) (2019-07-20)
'Foamy' alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administered amiodarone is currently used as a model of pulmonary phospholipidosis and it was
Haruka Okamoto et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1051, 33-40 (2017-03-13)
Cationic amphiphilic drugs (CADs) can induce the hyperaccumulation of phospholipids in cells and tissues. This side effect, which is known as drug-induced phospholipidosis, is sometimes problematic in the development and clinical use of CADs. It is known that CADs generally
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A8423-10G | 04061833391594 |
| A8423-5G | 04061833391617 |
| A8423-1G | 04061833391600 |
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