A8398
7-氨基去乙酰氧基头孢烷酸
别名:
7-ADCA
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关于此项目
经验公式（希尔记法）:
C8H10N2O3S
化学文摘社编号:
分子量:
214.24
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
244-870-1
MDL number:
InChI key
NVIAYEIXYQCDAN-CLZZGJSISA-N
InChI
1S/C8H10N2O3S/c1-3-2-14-7-4(9)6(11)10(7)5(3)8(12)13/h4,7H,2,9H2,1H3,(H,12,13)/t4-,7-/m1/s1
SMILES string
CC1=C(N2[C@H](SC1)[C@H](N)C2=O)C(O)=O
form
powder or crystals
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
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General description
化学结构:β-内酰胺
Application
7-氨基去乙酰氧基头孢烷酸用于头孢菌素的合成和生物转化研究。
Biochem/physiol Actions
7-ADCA是由产黄青霉菌产生的青霉素G生产的，涉及几个污染的化学步骤，然后使用青霉素酰化酶进行酶脱酰。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Other Notes
保存于密闭容器内，置于干燥通风处。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase.
Linda G. Otten, Charles F. Sio, et al.
Chembiochem, 6, 820-825 (2004)
Charles F Sio et al.
Biochemical and biophysical research communications, 312(3), 755-760 (2003-12-19)
Residue Phe375 of cephalosporin acylase has been identified as one of the residues that is involved in substrate specificity. A complete mutational analysis was performed by substituting Phe375 with the 19 other amino acids and characterising all purified mutant enzymes.
F Cui et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 38(4), 300-303 (2003-01-29)
Cephradine was synthesized by gamma-alumina-immobilized form of the penicillin G acylase of Bacillus megaterium with D-phenyglycine methylester hydrochloride (CH DGME.HCl) as acyl donor and 7-aminodeacetoxycephalosporanic acid (7-ADCA) as acyl acceptor. 0.1 g of 7-ADCA was dissolved by adding 2.5 ml
Ye-Wang Zhang et al.
Preparative biochemistry & biotechnology, 38(2), 129-138 (2008-03-06)
Enzymatic syntheses of cefaclor by immobilized penicillin acylase under kinetic control were carried out. According to the initial reaction rate ratio of synthesis to hydrolysis (Vs/Vh), penicillin acylase from Alcaligenes faecalis was chosen as the suitable catalyst for the synthesis
Maxim I Youshko et al.
Biotechnology and bioengineering, 85(3), 323-329 (2004-01-30)
Advantages of performing penicillin acylase-catalyzed synthesis of new penicillins and cephalosporins by enzymatic acyl transfer to the beta-lactam antibiotic nuclei in the supersaturated solutions of substrates have been demonstrated. It has been shown that the effective nucleophile reactivity of 6-aminopenicillanic
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