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类型
Grade II
质量水平
形式
salt-free, lyophilized powder
比活
300-1,500 units/mg protein
UniProt登记号
储存温度
−20°C
基因信息
pig ... ACY1(396930)
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应用
猪肾中的酰化酶I已被用于研究各种S-烷基-N-乙酰基-L-半胱氨酸及其碳、氧类似物的酰化酶I催化的脱乙酰作用。 酰化酶I可能有助于催化N-乙酰氨基酸生成对映体纯的 L-氨基酸。
生化/生理作用
酰化酶I是一种锌金属蛋白，可催化非天然和很少发生的α氨基酸的动力学分解。它对N-酰基L-α-氨基酸水解的对映选择性几乎是绝对的，但它接受具有广泛结构和功能性的底物。酰化酶I催化N-乙酰基-L-半胱氨酸和S-烷基-N-乙酰基-L-半胱氨酸的脱乙酰化。正丁基丙二酸是酰化酶I的抑制剂。S-烷基-N-乙酰基-L-半胱氨酸与短(C0-C3)和不分枝S-烷基取代已被发现是良好的酰化酶I底物。
单位定义
一个单元将在pH 7.0和25℃条件下每小时水解1.0 μmole N-乙酰-L-蛋氨酸。
分析说明
通过缩二脲法测定的蛋白质。
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Kinetic resolution of unnatural and rarely occurring amino acids: enantioselective hydrolysis of N-acyl amino acids catalyzed by acylase I
Chenault HK, et al.
Journal of the American Chemical Society, 111(16), 6354-6364 (1989)
V Uttamsingh et al.
Chemical research in toxicology, 11(7), 800-809 (1998-07-22)
The aminoacylase that catalyzes the hydrolysis of N-acetyl-L-cysteine (NAC) was identified as acylase I after purification by column chromatography and electrophoretic analysis. Rat kidney cytosol was fractionated by ammonium sulfate precipitation, and the proteins were separated by ion-exchange column chromatography
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