产品名称
抗-β-淀粉样蛋白（1-40） 兔抗, whole antiserum
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
15 mM sodium azide
species reactivity
human
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using human Alzheimer’s disease (AD) brain tissue
indirect ELISA: 1:4000-1:8000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
Application
兔抗-β-淀粉样蛋白（1-40）抗体可用于：
- Aβ肽的免疫细胞化学定位
- 免疫细胞化学
- 免疫沉淀
- 聚集超声微泡增强抗体递送（FUS-MB）
Biochem/physiol Actions
β-淀粉样蛋白前体蛋白 (APP) 是由蛋白水解酶β-分泌酶 (BACE1) 和 γ-分泌酶依次裂解，生成以Aβ1-42和 Aβ1-40型为主的β-淀粉样蛋白 (Aβ) 肽。分泌的Aβ肽通过再吸收机制和之后的内体降解过程降解，或通过胞外胰岛素降解酶降解。Aβ的胞外积累导致聚集体和原纤维的形成，最终形成淀粉样蛋白沉着物神经炎斑，其是阿尔茨海默病 (AD) 的标志物。
兔抗-β-淀粉样蛋白 (1-40) 抗体不会对正常脑组织的对照部分进行染色。
兔抗-β-淀粉样蛋白 (1-40) 抗体不会对正常脑组织的对照部分进行染色。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
General description
淀粉样蛋白前体蛋白（APP）是分子量70 kDa的跨膜糖蛋白家族的成员，存在于多种组织中。APP在大脑中表达。它位于人类21号染色体上。APP具有3种主要同种型，即APP695、APP751和APP770，它们来自于细胞的可变剪接事件。
Immunogen
与BSA偶联的合成β-淀粉样蛋白(1-40)。
Physical form
兔抗-β-淀粉样蛋白(1-40)以包含0.1％叠氮化钠（作为防腐剂）的液体形式提供。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Jonathan P T Corcoran et al.
The European journal of neuroscience, 20(4), 896-902 (2004-08-13)
We have disrupted the retinoid signalling pathway in adult rats by a dietary deficiency of vitamin A. After 1 year of this dietary deficiency, there was a deposition of amyloid beta in the cerebral blood vessels. There is a downregulation
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing
Benjannet S, et al.
Biochemical and Biophysical Research Communications, 325(1), 235-242 (2004)
Learning performances, brain NGF distribution and NPY levels in transgenic mice expressing TNF-alpha
Fiore M, et al.
Behavioural Brain Research, 112(1), 165-175 (2000)
Yanfang Rui et al.
Molecular brain, 9(1), 79-79 (2016-08-19)
Small oligomeric forms of amyloid-β (Aβ) are believed to be the culprit for declined brain functions in AD in part through their impairment of neuronal trafficking and synaptic functions. However, the precise cellular actions of Aβ oligomers and underlying mechanisms
S Benjannet et al.
The Journal of biological chemistry, 276(14), 10879-10887 (2001-01-22)
Processing of the beta-amyloid precursor protein (betaAPP) by beta- and gamma-secretases generates the amyloidogenic peptide Abeta, a major factor in the etiology of Alzheimer's disease. Following the recent identification of the beta-secretase beta-amyloid-converting enzyme (BACE), we herein investigate its zymogen
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