生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
fractionated antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
human
包装
vial of 2 mL lyophilized antiserum
技术
Ouchterlony double diffusion: suitable
indirect ELISA: 1:4,000-1:6,000
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... AMY1A(276)
一般描述
α-淀粉酶主要在唾液腺和胰腺中大量产生。在空肠和乳腺中也可表达。编码α淀粉酶的基因是位于1号染色体短臂上的AMY1和AMY2。AMY1负责在唾液和乳腺中产生这种酶，而AMY2则在胰腺中合成这种酶。AMY1也在某些肿瘤组织中表达。哺乳动物淀粉酶由三个结构域（A、B和C）组成。结构域A包含具有两个天冬氨酸和一个谷氨酸残基的活性位点。结构域B毗邻活性位点区，它是维持蛋白质构象是必不可少的结构。结构域C涉及催化机理。
特异性
该抗血清对在人唾液和人胰腺提取物中发现的人α-淀粉酶具有特异性。未观察到与其他人唾液蛋白或胰腺提取蛋白的反应。
免疫原
人唾液α-淀粉酶。
应用
兔源抗α-淀粉酶抗体可用于免疫荧光和免疫组织化学分析。
兔源抗α淀粉酶抗体还被用于免疫细胞化学分析。
将小鼠胰腺切片固定在4％多聚甲醛中，并使用兔抗淀粉酶抗体以1：100的稀释度用于免疫组织化学。
生化/生理作用
α--淀粉酶对于催化淀粉消化的第一步是必不可少的，淀粉消化是人类饮食中碳水化合物的主要来源。α-淀粉酶水解多糖，最终生成的主要产物为麦芽糖、麦芽三糖和极限糊精。
外形
由 0.01M 的磷酸缓冲盐溶液 (pH 7.2) 冻干
重悬
用 2 mL 去离子水复溶。
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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Butterworth PJ, et al.
Starch/Staerke, 63(7), 395-405 (2011)
Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean
Malatesta M, et al.
Journal of Anatomy, 201(5), 409-415 (2002)
Maho Kodama et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 56(1), 33-44 (2007-09-19)
In this study, we describe pancreatic cell ontogeny in renal capsule-transplanted embryonic stem cells (ES) after injury by streptozocin (STZ), showing pancreatogenesis in situ. Seven-week-old female BALB/c nude mice were treated with either a single 175- or 200-mg/kg STZ dose
Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F.
Jared S Elenbaas et al.
Gastroenterology, 154(6), 1625-1629 (2018-01-26)
Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but lamin function in the
Angela Criscimanna et al.
Gastroenterology, 147(5), 1106-1118 (2014-08-17)
Although the cells that contribute to pancreatic regeneration have been widely studied, little is known about the mediators of this process. During tissue regeneration, infiltrating macrophages debride the site of injury and coordinate the repair response. We investigated the role
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