所有图片(1)
About This Item
经验公式（希尔记法）:
C23H13Cl2N3O2
CAS号:
分子量:
434.27
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥97% (HPLC)
表单
powder
溶解性
DMSO: 2 mg/mL, clear (warmed)
H2O: insoluble
储存温度
room temp
SMILES字符串
Clc1ccc(Cl)c(c1)-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2
InChI
1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
InChI key
SVENPFFEMUOOGK-SDNWHVSQSA-N
应用
AGK2是一种SIRT2抑制剂。AGK2已被用于研究中以确定SIRT2抑制能够诱导细胞死亡并降低细胞内ATP水平。在帕金森病模型中，AGK2还能防止α突触核蛋白毒性对多巴胺神经元的损害。
生化/生理作用
AGK2是一种SIRT2抑制剂。在帕金森病模型中，AGK2能防止α突触核蛋白毒性对多巴胺神经元的损害。对SIRT2的IC50 = 3.5 uM。AGK2对SIRT2的选择性是SIRT1和SIRT3的15倍左右。AGK2可能是选择性最高的SIRT2抑制剂。
AGK2是一种SIRT2抑制剂；在帕金森病模型中，AGK2能防止α突触核蛋白毒性对多巴胺神经元的损害。
特点和优势
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hai-Bo Yu et al.
International journal of medical sciences, 15(12), 1356-1364 (2018-10-03)
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD +)-dependent class III histone deacetylase. We have reported that HBx (hepatitis B virus X protein)-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. However, the potential anti-HBV effect of AGK2, a selective inhibitor
David T She et al.
Molecular neurobiology, 55(12), 9188-9203 (2018-04-15)
Sirtuin 2 (SIRT2) is a family member of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases which appears to have detrimental roles in an array of neurological disorders such as Parkinson's disease (PD) and Huntington's disease (HD). In light of the recently emerging
Lisa M Giammona et al.
Experimental hematology, 37(11), 1340-1352 (2009-09-01)
Megakaryocytic cells (Mks) undergo endomitosis and become polyploid. Mk ploidy correlates with platelet production. We previously showed that nicotinamide (NIC) greatly increases Mk ploidy in cultures of human mobilized peripheral blood CD34(+) cells. This study aims to examine the generality
G L Garrote et al.
The Journal of dairy research, 68(4), 639-652 (2002-04-04)
Chemical and microbiological composition of four Argentinean kefir grains from different sources as well as characteristics of the corresponding fermented milk were studied. Kefir grains CIDCA AGK1, AGK2 and AGK4 did not show significant differences in their chemical and microbiological
Sapna Singh et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(8), 6159-6171 (2015-03-22)
Sirtuins belong to the family of class III histone deacetylases; its role in neoplasia is controversial as both tumor-suppressive and promoting functions have been reported. There are very few reports available, where expressions of sirtuin isoforms are comprehensively analyzed during
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