产品名称
吖啶黄, fluorescent label
Quality Level
form
powder
technique(s)
microbe id | staining: suitable
mp
179-181 °C
solubility
H2O: 0.33 g/mL (lit.)(lit.)
εmax
≥48000 at 459-465 nm in methanol at 0.004 g/L, ≥50000 at 259-265 nm in methanol at 0.004 g/L
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
[Cl-].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46
InChI
1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H
InChI key
PEJLNXHANOHNSU-UHFFFAOYSA-N
Application
- 已将吖啶黄用于凝集测试，以区分 羊种布氏杆菌 的光滑型和粗糙型菌落形成。
- 曾被用作 Ago2 (argonaute 2) 抑制剂。
- 已被用作 HIF-ARNT（缺氧诱导因子-芳香烃受体核转位因子）复合物形成的抑制剂。
- 已用于研究 鱼肉杆菌产生细菌素 。
吖啶黄用于荧光标记高分子量 RNA 分子 。
各种溶剂中的激发和发射波长 ：
不溶于乙醚、氯仿和固定油。在荧光稳态测量中用作供体分子（当与罗丹明 6G 作为受体配对时），起到 pH 传感器的作用 。
各种溶剂中的激发和发射波长 ：
- 甲醇：λex = 424 nm；λem = 518 nm
- 乙醇：λex = 426 nm；λem = 524 nm
- 丙醇：λex = 430 nm；λem = 512 nm
- 丁醇：λex = 430 nm；λem = 526 nm
- 甲酰胺：λex = 434 nm；λem = 524 nm
- 甘油：λex = 432 nm；λem = 540 nm
- 水：λex = 416 nm；λem = 514 nm
不溶于乙醚、氯仿和固定油。在荧光稳态测量中用作供体分子（当与罗丹明 6G 作为受体配对时），起到 pH 传感器的作用 。
Biochem/physiol Actions
吖啶黄也与 HIF-1α 相互作用（缺氧诱导因子 1α）和 HIF-2α从而抑制 HIF-1 的二聚体形成和转录功能。对肿瘤生长和血管形成也有负面影响。吖啶黄素还具有杀锥虫、抗菌和抗病毒活性。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Isolation and biotyping of Brucella melitensis from aborted sheep and goat fetuses.
Buyukcangaz E, et al.
Turkish Journal of Veterinary and Animal Sciences, 33, 311-316 (2009)
The contribution of bacteriocin to inhibition of Listeria monocytogenes by Carnobacterium piscicola strains in cold-smoked salmon systems.
Nilsson L, et al.
Journal of Applied Microbiology, 96, 133-133 (2004)
Shizuka Nakayama et al.
Chemical communications (Cambridge, England), 47(16), 4766-4768 (2011-03-15)
The ubiquitous bacterial biofilm regulator, c-di-GMP can form G-quadruplexes at physiological conditions in the presence of some aromatic compounds, such as acriflavine and proflavine. The fluorescence of these compounds is quenched upon c-di-GMP binding and some of the formed c-di-GMP
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A8126-100G | 04061832340005 |
| A8126-25G | 04061833391211 |