所有图片(3)
About This Item
经验公式（希尔记法）:
C14H14ClN3
CAS号:
分子量:
259.73
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47
推荐产品
产品名称
吖啶黄, fluorescent label
质量水平
表单
powder
技术
microbe id | staining: suitable
mp
179-181 °C
溶解性
H2O: 0.33 g/mL (lit.)(lit.)
εmax
≥48000 at 459-465 nm in methanol at 0.004 g/L
≥50000 at 259-265 nm in methanol at 0.004 g/L
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
[Cl-].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46
InChI
1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H
InChI key
PEJLNXHANOHNSU-UHFFFAOYSA-N
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应用
- 已将吖啶黄用于凝集测试，以区分 羊种布氏杆菌 的光滑型和粗糙型菌落形成。
- 曾被用作 Ago2 (argonaute 2) 抑制剂。
- 已被用作 HIF-ARNT（缺氧诱导因子-芳香烃受体核转位因子）复合物形成的抑制剂。
- 已用于研究 鱼肉杆菌产生细菌素 。
吖啶黄用于荧光标记高分子量 RNA 分子 。
各种溶剂中的激发和发射波长 ：
不溶于乙醚、氯仿和固定油。在荧光稳态测量中用作供体分子（当与罗丹明 6G 作为受体配对时），起到 pH 传感器的作用 。
各种溶剂中的激发和发射波长 ：
- 甲醇：λex = 424 nm；λem = 518 nm
- 乙醇：λex = 426 nm；λem = 524 nm
- 丙醇：λex = 430 nm；λem = 512 nm
- 丁醇：λex = 430 nm；λem = 526 nm
- 甲酰胺：λex = 434 nm；λem = 524 nm
- 甘油：λex = 432 nm；λem = 540 nm
- 水：λex = 416 nm；λem = 514 nm
不溶于乙醚、氯仿和固定油。在荧光稳态测量中用作供体分子（当与罗丹明 6G 作为受体配对时），起到 pH 传感器的作用 。
生化/生理作用
吖啶黄也与 HIF-1α 相互作用（缺氧诱导因子 1α）和 HIF-2α从而抑制 HIF-1 的二聚体形成和转录功能。对肿瘤生长和血管形成也有负面影响。吖啶黄素还具有杀锥虫、抗菌和抗病毒活性。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Both preclinical and clinical studies suggest that brief cycles of ischemia and reperfusion in the arm or leg may protect the heart against injury following prolonged coronary artery occlusion and reperfusion, a phenomenon known as remote ischemic preconditioning. Recent studies
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Acriflavine resistance protein B acts as the active transporter in the multi-drug efflux pump Acriflavine resistance proteins A / B - Tolerance to colicins protein in Escherichia coli. Within the same reaction cycle intermediate all Acriflavine resistance protein B X-ray
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Hypoxia-inducible factors (HIFs) accumulate in both neoplastic and inflammatory cells within the tumor microenvironment and impact the progression of a variety of diseases, including colorectal cancer. Pharmacological HIF inhibition represents a novel therapeutic strategy for cancer treatment. We show here
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