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生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15 μg/mL
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
基因信息
human ... ACVR2A(92)
一般描述
Activin is a disulfide-linked dimeric protein released by granulosa cells in the ovary and sertoli cells in the testis. It has several functions which include bone remodeling, neural cell differentiation, reproductive physiology, hematopoiesis and mesoderm induction. Activin will not bind directly to Type I activin receptors rather it will associate with the type II receptor-activin complex and start signal transduction. Activin Receptor IIA belongs to Ser/Thr protein kinase family, is highly conserved and can bind to inhibin, BMP-2, and BMP-7 with lower affinities. Goat anti-activin receptor IIA antibody reacts specifically with recombinant human activin receptor IIA. The antibody exhibits approximately 2% cross-reactivity with recombinant human activin receptor I and recombinant human activin receptor IIB.
The antibody has the ability to block receptor-ligand interaction. In ELISA assays, it will block 50% of the binding of recombinant human activin A to recombinant human activin receptor IIA/Fc chimera.
免疫原
recombinant human activin receptor IIA expressed in Sf 21 insect cells.
应用
Anti-Activin Receptor IIA antibody can be used in in western blotting (working concentration:-0.1-0.2 μg/mL) and indirect ELISA (working concentration -0.5-1.0 μg/mL) for detecting human activin receptor IIA.
Goat Activin Receptor IIA antibody is suitable for immunohistochemistry assays at 15μg/ml.
Goat anti-Activin receptor IIB (ActRIIB) was used to detect activin receptor IIB in muscle fibroblasts by western blot. The antibody recognized activin receptor IIB at roughly 50kDa.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
J C Smith et al.
Cell, 67(1), 79-87 (1991-10-04)
The Brachyury (T) gene is required for mesoderm formation in the mouse. In this paper we describe the cloning and expression of a Xenopus homolog of Brachyury, Xbra. As with Brachyury in the mouse, Xbra is expressed in presumptive mesodermal
Magnus Diller et al.
Arthritis research & therapy, 21(1), 144-144 (2019-06-12)
Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA). The impact of both proteins on the behavior of synovial fibroblasts (SF) in RA as well as in osteoarthritis (OA) is unknown. Immunohistochemical
S Y Ying et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 214(2), 114-122 (1997-02-01)
Activin and inhibin, members of transforming growth factor-beta (TGFbeta) superfamily, have diverse and widespread effects within living organisms at many stages during growth and development. From the initial isolation of these growth factors based on their effects of FSH secretion
J P de Winter et al.
Endocrinology, 132(3), 975-982 (1993-03-01)
The production of activin by Sertoli cells isolated from 21-day-old rats was studied using the mesoderm-inducing activity of activin on Xenopus laevis animal cap explants, immunoprecipitation and Western blotting. Furthermore, the effects of recombinant bovine activin-A on rat Sertoli cell
L Attisano et al.
Cell, 75(4), 671-680 (1993-11-19)
Transforming growth factor beta (TGF beta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases
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