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Merck
CN

A8052

Sigma-Aldrich

Arg-Gly-Asp

≥97% (TLC)

别名:

L-arginyl-glycyl-L-aspartic acid

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About This Item

经验公式(希尔记法):
C12H22N6O6
CAS号:
分子量:
346.34
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32

生物来源

synthetic

质量水平

方案

≥97% (TLC)

表单

powder

技术

cell culture | stem cell: suitable

UniProt登记号

储存温度

−20°C

SMILES字符串

N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1

InChI key

IYMAXBFPHPZYIK-BQBZGAKWSA-N

基因信息

human ... FN1(2335)

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Amino Acid Sequence

Arg-Gly-Asp

一般描述

Arg-Gly-Asp(RGD)是整合素结合位点,属于粘附蛋白类。它可作为脑肿瘤靶向配体。

应用

Arg-Gly-Asp用于:
  • 使细胞表面Arg-Gly-Asp(RGD)受体饱和,抑制骨髓基质细胞(MSC)与肽修饰水凝胶的粘附
  • 粘附检测
  • 抑制实验,以证实细胞粘附的β1-整合素依赖性
  • 纺织品制造和RGD纺织品功能化
  • 构建迁移受损的人真皮成纤维细胞群
  • 修饰玻璃衬底并评估人骨髓间充质干细胞(hBM-MSC)的行为
  • 人乳腺上皮细胞的细胞培养

生化/生理作用

一级序列涉及蛋白与细胞表面的结合

包装

无底玻璃瓶。内容物在嵌入的融合锥中。

制备说明

来自纤连蛋白的细胞粘附结构域的三肽

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

Lot/Batch Number

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访问文档库

Bio-active molecules modified surfaces enhanced mesenchymal stem cell adhesion and proliferation
Mobasseri R, et al.
Biochemical and biophysical research communications, 483(1), 312-317 (2017)
Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.
Lawler J, et al.
The Journal of cell biology, 107(6), 2351-2361 (1988)
Functional role of Arg-Gly-Asp (RGD)-binding sites on beta1 integrin in embryo implantation using mouse blastocysts and human decidua
Shiokawa S, et al.
Biology of Reproduction, 60(6), 1468-1474 (1999)
Leo J Hofland et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 46 Suppl 1, 191S-198S (2005-01-18)
The presence of a high density of somatostatin receptors (SSRs) on human tumors forms the basis for the successful visualization of primary tumors and their metastases using radiolabeled somatostatin analogs. In recent years somatostatin analogs, coupled to beta-emitting radioisotopes, have
Stijn F M van Dongen et al.
Advanced materials (Deerfield Beach, Fla.), 25(12), 1687-1691 (2013-01-29)
There's an APP for that: cell-repellent APP (azido-[polylysine-g-PEG]) is used to create substrates for spatially controlled dynamic cell adhesion. The simple addition of a functional peptide to the culture medium rapidly triggers cell adhesion. This highly accessible yet powerful technique

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