A8052
Arg-Gly-Asp
≥97% (TLC)
别名:
L-arginyl-glycyl-L-aspartic acid
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关于此项目
经验公式（希尔记法）:
C12H22N6O6
化学文摘社编号:
分子量:
346.34
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Form:
powder
Assay:
≥97% (TLC)
Biological source:
synthetic
InChI
1S/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1
SMILES string
N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O
InChI key
IYMAXBFPHPZYIK-BQBZGAKWSA-N
biological source
synthetic
assay
≥97% (TLC)
form
powder
technique(s)
cell culture | stem cell: suitable
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... FN1(2335)
General description
Arg-Gly-Asp（RGD）是整合素结合位点，属于粘附蛋白类。它可作为脑肿瘤靶向配体。
Application
Arg-Gly-Asp用于：
- 使细胞表面Arg-Gly-Asp（RGD）受体饱和，抑制骨髓基质细胞（MSC）与肽修饰水凝胶的粘附
- 粘附检测
- 抑制实验，以证实细胞粘附的β1-整合素依赖性
- 纺织品制造和RGD纺织品功能化
- 构建迁移受损的人真皮成纤维细胞群
- 修饰玻璃衬底并评估人骨髓间充质干细胞（hBM-MSC）的行为
- 人乳腺上皮细胞的细胞培养
Biochem/physiol Actions
一级序列涉及蛋白与细胞表面的结合
Packaging
无底玻璃瓶。内容物在嵌入的融合锥中。
Preparation Note
来自纤连蛋白的细胞粘附结构域的三肽
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Bio-active molecules modified surfaces enhanced mesenchymal stem cell adhesion and proliferation
Mobasseri R, et al.
Biochemical and biophysical research communications, 483(1), 312-317 (2017)
Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.
Lawler J, et al.
The Journal of cell biology, 107(6), 2351-2361 (1988)
Functional role of Arg-Gly-Asp (RGD)-binding sites on beta1 integrin in embryo implantation using mouse blastocysts and human decidua
Shiokawa S, et al.
Biology of Reproduction, 60(6), 1468-1474 (1999)
Leo J Hofland et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 46 Suppl 1, 191S-198S (2005-01-18)
The presence of a high density of somatostatin receptors (SSRs) on human tumors forms the basis for the successful visualization of primary tumors and their metastases using radiolabeled somatostatin analogs. In recent years somatostatin analogs, coupled to beta-emitting radioisotopes, have
The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells
Yang F, et al.
Biomaterials, 26(30), 5991-5998 (2005)
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