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经验公式(希尔记法):
C6H8O6
化学文摘社编号:
分子量:
176.12
UNSPSC Code:
12352209
NACRES:
NA.26
PubChem Substance ID:
EC Number:
200-066-2
Beilstein/REAXYS Number:
84272
MDL number:
产品名称
L -抗坏血酸, reagent grade, crystalline
InChI key
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
InChI
1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
SMILES string
OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O
biological source
synthetic
grade
reagent grade
assay
≥98% ( with iodine, titration)
form
crystalline
technique(s)
HPLC: suitable
cell culture | stem cell: suitable
color
white to slightly yellow
pH
1.0-2.5 (25 °C, 176 g/L in water)
mp
190-194 °C (dec.)
solubility
water: soluble 50 mg/mL
storage temp.
room temp
Quality Level
Gene Information
human ... SLC23A2(9962)
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Application
L-抗坏血酸用于:
- 用作成软骨培养基成分,培养骨源性间充质干细胞(BMSC)(149)
- 用作高效液相色谱(HPLC)系统的参考标准品(150)
- 分析其对人类胃癌GES-1细胞和AGS细胞的影响(151)
Biochem/physiol Actions
L-抗坏血酸缺乏与L-古洛糖酸-1,4-内酯氧化酶(GLO)酶缺乏有关。能引起抗氧化作用,并通过抗坏血酸自由基中间体氧化为脱氢抗坏血酸。L-抗坏血酸对于维持氧化还原平衡至关重要。是多巴胺-β羟化酶的辅酶,有利于T细胞增殖,保护免疫系统,缓解普通感冒症状。
抗坏血酸,也被称为维生素C,是一种六碳内酯,由植物和一些动物产生,但是人和其他灵长类无法产生。抗坏血酸是多种酶的辅酶,可用作单加氧酶和双加氧酶的电子公里。抗坏血酸没还是强大的抗氧化剂,特别是对于活性氧化簇很有效。
Disclaimer
储存期间颜色可变暗。
General description
L-抗坏血酸的生物合成途径在植物,动物和真菌中有所不同。在L-古洛糖酸-1,4-内酯氧化酶(GLO)的作用下,由L-古洛糖酸-1,4-内酯合成。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Frontiers in Physiology, 6, 397-397 (2015)
Vitamin C in disease prevention and cure: an overview
Chambial S, et al.
Indian Journal of Clinical Biochemistry : IJCB, 28(4), 314-328 (2013)
Takashi Yoshida et al.
Nature chemical biology, 2(11), 596-607 (2006-09-26)
Transient receptor potential (TRP) proteins form plasma-membrane cation channels that act as sensors for diverse cellular stimuli. Here, we report a novel activation mechanism mediated by cysteine S-nitrosylation in TRP channels. Recombinant TRPC1, TRPC4, TRPC5, TRPV1, TRPV3 and TRPV4 of
Marc P Bradshaw et al.
Critical reviews in food science and nutrition, 51(6), 479-498 (2011-09-21)
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