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生物来源
rabbit
质量水平
偶联物
agarose conjugate
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
分析物化学类别
proteins (c-Myc)
技术
affinity chromatography: suitable
immunoprecipitation (IP): suitable
容量
≥10 nmol/mL binding capacity (c-Myc tagged fusion protein)
≥7 nmol/mL elution capacity (c-Myc tagged fusion protein)
UniProt登记号
储存温度
2-8°C
基因信息
human ... MYC(4609)
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一般描述
人c-Myc原癌基因属于MYC癌基因家族，是在几种致白血病逆转录病毒中发现的禽v-Myc基因的人细胞同源物。c-Myc基因位于人类染色体8q24.21。其两个主结构域包括具有螺旋-环-螺旋/亮氨酸-拉链基序的N末端盒区域和C末端基本区域
特异性
抗c-Myc可识别位于c-Myc标记融合蛋白上的表位。
免疫原
人p62c-Myc蛋白的合成肽。
应用
兔源抗c-Myc琼脂糖亲和凝胶抗体已用于：
- 染色质免疫沉淀 (ChIP)
- 免疫共沉淀
- 蛋白质印迹
- 免疫荧光
- 免疫沉淀
生化/生理作用
许多人类肿瘤中观察到c-Myc原癌基因表达增加。在血管肉瘤中观察到Myc基因位点扩增，在伯基特氏淋巴瘤中Myc基因位点出现易位。c-Myc是主要的调控基因，可靶向多种代谢事件。位于人c-Myc氨基酸残基410-419（EQKLISEEDL）内的表位已在许多表达载体中广泛用作标签，使蛋白质能够作为c-Myc标记融合蛋白进行表达。抗c-Myc琼脂糖可用于纯化细菌裂解液或转染细胞中表达的c-Myc标记融合蛋白。
外形
悬浮的琼脂糖颗粒(1：1，v/v)溶于0.01 M磷酸盐缓冲液中，含有15mM叠氮化钠。
储存及稳定性
为持续使用并延长存储时间，请2°C至8°C存储。请勿冷冻。
免责声明
除非我们的产品目录另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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