推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
fractionated antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~70 kDa (several isonform bands)
种属反应性
rat, mouse, human
技术
western blot: 1:500-1:1,000 using whole extracts of human A549 cells, rat PC12 cells, and HEK-293T cells expressing mouse Atg16l
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ATG16L1(55054)
mouse ... Atg16l1(77040)
rat ... Atg16l1(363278)
一般描述
ATG16L is a component of a large protein complex that is critical for autophagy.
Autophagy-related 16-like 1 (ATG16L1) is an autophagy gene, that is expressed in the colon, small intestine, intestinal epithelial cells, leukocytes and spleen. Atg16L is expressed in different isoform patterns depending on the tissue.
免疫原
synthetic peptide correspopnding to amino acids 2-15 of mouse Atg16l, conjugated to KLH via a C-terminal cysteine residue. The corresponding sequence is identical in rat and human.
应用
Anti-Atg16L antibody produced in rabbit has been used in western blotting.
生化/生理作用
Atg16L is involved in LC3 lipidation during the formation of autphagosomes. Studies have reported that Atg16L may also function as a mammalian Rab33 effector.
Autophagy-related 16-like 1 (ATG16L1) modulates host immune responses and is linked with several diseases, like cardiovascular disease (CVD). Atg16 multimeric complex plays an essential role in autophagy. Atg16L interacts with both Atg5 and additional Atg16L monomers. Together with Atg12-Atg5 conjugate, Atg16L associates with the autophagic isolation membrane for the duration of autophagosome formation.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Bin Cao et al.
JCI insight, 1(21), e86654-e86654 (2016-12-27)
The placenta is a barrier against maternal-fetal transmission of pathogens. Placental infections can cause several adverse pregnancy outcomes, including preterm birth (PTB). Yet, we have limited knowledge regarding the mechanisms the placenta uses to control infections. Here, we show that
Yong Chen et al.
Scientific reports, 2, 808-808 (2012-11-15)
We compared the expression levels of 307 miRNAs in six different B16F1 melanoma cell lines of differing malignant properties and found that the miR-290-295 cluster showed a strong upregulation in the more malignant B16F1 daughter cell lines. Its overexpression in
Human papillomavirus 16E6/E7 activates autophagy via Atg9B and LAMP1 in cervical cancer cells
Tingting C, et al.
Cancer medicine (2019)
Vanessa M Hubbard-Lucey et al.
Immunity, 41(4), 579-591 (2014-10-14)
Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. Here we find that Atg16L1 deficiency leads to an exacerbated graft-versus-host disease (GVHD) in a
Mitsunori Fukuda et al.
Autophagy, 4(6), 824-826 (2008-08-02)
Atg16L is a factor that is essential for elongation of the isolation membrane (also called phagophore), a precursor of the autophagosome. Atg16L facilitates LC3/Atg8-conjugation to phosphatidylethanolamine by forming an oligomeric complex with Atg12-conjugated Atg5 and recruiting an LC3-Atg3 intermediate to
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