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Merck
CN

A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

别名:

Ac-QKLVFF-NH2, amyloid blocker

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关于此项目

经验公式（希尔记法）:
C42H63N9O8
化学文摘社编号:
189064-06-0
分子量:
822.01
NACRES:
NA.32
PubChem Substance ID:
329770908
UNSPSC Code:
12352202
MDL number:
MFCD17215285
Form:
powder
Assay:
≥97% (HPLC)

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InChI

1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O

InChI key

DDXTVYDSGCHGAN-PITCCTKHSA-N

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P05067

storage temp.

−20°C

Quality Level

200

Gene Information

human ... APP(351)

Biochem/physiol Actions

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
067H0822

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L O Tjernberg et al.
The Journal of biological chemistry, 271(15), 8545-8548 (1996-04-12)
Polymerization of amyloid beta-peptide (Abeta) into amyloid fibrils is a critical step in the pathogenesis of Alzheimer's disease. Here, we show that peptides incorporating a short Abeta fragment (KLVFF; Abeta16-20) can bind full-length Abeta and prevent its assembly into amyloid
L O Tjernberg et al.
The Journal of biological chemistry, 272(19), 12601-12605 (1997-05-09)
We have previously shown that short peptides incorporating the sequence KLVFF can bind to the approximately 40amino acid residue Alzheimer amyloid beta-peptide (Abeta) and disrupt amyloid fibril formation (Tjernberg, L. O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A. R.

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