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Merck
CN

A6908

Sigma-Aldrich

乙酰丙嗪 马来酸盐

≥98% (HPLC)

别名:

2-乙酰基-10-(3-二甲基氨基丙基)吩噻嗪 马来酸盐, 乙酰丙嗪 马来酸盐

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About This Item

经验公式(希尔记法):
C19H22N2OS · C4H4O4
CAS号:
分子量:
442.53
EC 号:
MDL编号:
UNSPSC代码:
12352200

方案

≥98% (HPLC)

表单

powder

储存条件

protect from light

颜色

yellow

溶解性

H2O: >10 mg/mL

储存温度

room temp

SMILES字符串

OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O

InChI

1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

FQRHOOHLUYHMGG-BTJKTKAUSA-N

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生化/生理作用

乙酰丙嗪是一种吩噻嗪类抗精神病药,仅用作兽药(马、狗和猫)。该化合物是抗精神病药物氯丙嗪(#C8138)的类似物。该药物被认为可以阻断大脑中的多巴胺受体。最近发现该化合物抑制 ABCG2 转运蛋白,该蛋白在肿瘤中的过表达与耐药性有关。
非典型抗精神病药。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

危险分类

Acute Tox. 3 Oral - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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P V Scrivani et al.
American journal of veterinary research, 59(10), 1227-1233 (1998-10-22)
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P M Taylor
Veterinary surgery : VS, 28(1), 77-82 (1999-02-20)
To investigate whether hypertonic saline infusion would prevent hypotension and pituitary-adrenocortical axis activation during halothane anesthesia after acepromazine premedication and thiopental induction in sheep. Randomized crossover study. Six Welsh Mountain ewes weighing 40+/-2 kg and aged 2 to 3 years.
J M McGree et al.
Journal of veterinary pharmacology and therapeutics, 36(1), 31-42 (2013-01-16)
We describe the population pharmacokinetics of an acepromazine (ACP) metabolite (2-(1-hydroxyethyl)promazine) (HEPS) in horses for the estimation of likely detection times in plasma and urine. ACP (30 mg) was administered to 12 horses, and blood and urine samples were taken
Bobbi J Conner et al.
American journal of veterinary research, 73(5), 595-601 (2012-04-27)
To evaluate the effect of acepromazine maleate administered IV on platelet function assessed in healthy dogs by use of a modified thromboelastography assay. 6 healthy adult mixed-breed dogs. Dogs received each of 3 treatments (saline [0.9% NaCl] solution [1 to
Elisa Bortolami et al.
Veterinary anaesthesia and analgesia, 40(2), 181-193 (2012-06-27)
To investigate the safety, sedative and analgesic properties of methadone in combination with acepromazine prior to neutering in cats. Controlled clinical, block randomized, prospective, blinded study designed for regulatory purposes. 24 female and 21 male healthy cats. Cats received one

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