A6908
乙酰丙嗪 马来酸盐
≥98% (HPLC)
别名:
2-乙酰基-10-（3-二甲基氨基丙基）吩噻嗪 马来酸盐, 乙酰丙嗪 马来酸盐
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关于此项目
经验公式（希尔记法）:
C19H22N2OS · C4H4O4
化学文摘社编号:
分子量:
442.53
EC Number:
222-748-9
UNSPSC Code:
12352200
MDL number:
InChI key
FQRHOOHLUYHMGG-BTJKTKAUSA-N
InChI
1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
yellow
solubility
H2O: >10 mg/mL
storage temp.
room temp
Biochem/physiol Actions
乙酰丙嗪是一种吩噻嗪类抗精神病药，仅用作兽药（马、狗和猫）。该化合物是抗精神病药物氯丙嗪（＃C8138）的类似物。该药物被认为可以阻断大脑中的多巴胺受体。最近发现该化合物抑制 ABCG2 转运蛋白，该蛋白在肿瘤中的过表达与耐药性有关。
非典型抗精神病药。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
P V Scrivani et al.
American journal of veterinary research, 59(10), 1227-1233 (1998-10-22)
To determine whether acepromazine (ACE) and butorphanol (BUT) combination can be used for restraint of dogs during positive-contrast upper gastrointestinal tract (UGIT) examination. 6 healthy dogs. In a randomized crossover design study, weekly UGIT examinations were performed on each dog
P M Taylor
Veterinary surgery : VS, 28(1), 77-82 (1999-02-20)
To investigate whether hypertonic saline infusion would prevent hypotension and pituitary-adrenocortical axis activation during halothane anesthesia after acepromazine premedication and thiopental induction in sheep. Randomized crossover study. Six Welsh Mountain ewes weighing 40+/-2 kg and aged 2 to 3 years.
Bobbi J Conner et al.
American journal of veterinary research, 73(5), 595-601 (2012-04-27)
To evaluate the effect of acepromazine maleate administered IV on platelet function assessed in healthy dogs by use of a modified thromboelastography assay. 6 healthy adult mixed-breed dogs. Dogs received each of 3 treatments (saline [0.9% NaCl] solution [1 to
Elisa Bortolami et al.
Veterinary anaesthesia and analgesia, 40(2), 181-193 (2012-06-27)
To investigate the safety, sedative and analgesic properties of methadone in combination with acepromazine prior to neutering in cats. Controlled clinical, block randomized, prospective, blinded study designed for regulatory purposes. 24 female and 21 male healthy cats. Cats received one
J M McGree et al.
Journal of veterinary pharmacology and therapeutics, 36(1), 31-42 (2013-01-16)
We describe the population pharmacokinetics of an acepromazine (ACP) metabolite (2-(1-hydroxyethyl)promazine) (HEPS) in horses for the estimation of likely detection times in plasma and urine. ACP (30 mg) was administered to 12 horses, and blood and urine samples were taken
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