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Merck
CN
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主要文件

A6706

Sigma-Aldrich

O-乙酰基-L-肉碱盐酸盐 盐酸盐

≥99% (titration)

别名:

乙酰 L-肉碱盐酸盐, (R)-3-乙酰氧基-4-(三甲基铵)丁酸酯 盐酸盐, ALC, ALCAR, R-(-)-2-乙酰氧基-3-羧基- N,N,N -三甲基-1-丙胺氯化物

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100 MG
CN¥1,067.26
250 MG
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100 MG
CN¥1,067.26
250 MG
CN¥1,449.50

About This Item

经验公式(希尔记法):
C9H17NO4 · HCl
CAS号:
分子量:
239.70
Beilstein:
4340103
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.83

CN¥1,067.26


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产品名称

O-乙酰基-L-肉碱盐酸盐 盐酸盐, ≥99% (titration), powder

生物来源

synthetic

方案

≥99% (titration)

表单

powder

旋光性

[α]25/D −28°, c = 2 in H2O(lit.)

颜色

white to off-white

mp

194 °C

溶解性

H2O: 100 mg/mL

应用

cell analysis

储存温度

2-8°C

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一般描述

乙酰-L-肉碱(ALC/ALCAR)是一种类维生素,[1]作为肉碱代谢物存在于哺乳动物血浆和组织中。[2]它是L-肉碱(LC)的乙酰形式。[1]ALCAR可用作膳食补充剂。[2]它以高浓度存在于下丘脑中。[1]

应用

O-乙酰-L-肉碱盐酸盐已用于:
  • 作为生物活性分子体外研究其对B淋巴母细胞样细胞系(BLCL)增殖的影响以及对流感病毒特异性人B和T细胞免疫应答的调节作用[3]
  • 作为体外成熟(IVM)培养基组分,研究其对羔羊卵母细胞囊胚率、超微结构和线粒体DNA拷贝数的影响[4]
  • 作为代谢物/化学标准品对鼠肿瘤组织间液中的代谢物水平进行定量分析[5]

生化/生理作用

乙酰左旋肉碱(ALC)在中间代谢和提高女性生育力中起重要作用。女性生殖系统的氧化和代谢状态受到ALC调控。ALC具有拟胆碱[1]和抗炎功效。[2]它可调控γ-氨基丁酸(GABA)系统。[1]ALC能调节大脑的葡萄糖利用率。ALC对发育大脑具有神经保护作用。[2]
通过线粒体膜转运乙酰基的内源性线粒体代谢物。
通过线粒体膜转运乙酰基的内源性线粒体代谢物。外源性乙酰肉碱增强老年大鼠线粒体功能。作为辅酶 A 的醋酸盐供体,增加中枢和外周乙酰胆碱合成和功能。乙酰肉碱具有抗伤害感受性活性,可能通过增强毒蕈碱胆碱能受体或 mGlu2 谷氨酸受体的活性介导。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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