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Merck
CN

A6636

Aflatoxin B₁

greener alternative

from Aspergillus flavus, ≥98.0% (HPLC), powder, CYP1A2, CYP2A6, CYP2D6, and CYP3A family substrate

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关于此项目

经验公式（希尔记法）:
C17H12O6
化学文摘社编号:
1162-65-8
分子量:
312.27
NACRES:
NA.77
PubChem Substance ID:
24891116
UNSPSC Code:
12352200
EC Number:
214-603-3
MDL number:
MFCD00869647
Beilstein/REAXYS Number:
1269174

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产品名称

黄曲霉毒素B1 来源于黄曲霉, from Aspergillus flavus

InChI

1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1

InChI key

OQIQSTLJSLGHID-WNWIJWBNSA-N

SMILES string

COc1cc2OC3OC=CC3c2c4OC(=O)C5=C(CCC5=O)c14

biological source

Aspergillus flavus

assay

≥98.0% (HPLC)

form

powder

greener alternative product score

old score: 51
new score: 42
Find out more about DOZN™ Scoring

greener alternative product characteristics

Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

greener alternative category

Re-engineered,

storage temp.

2-8°C

Quality Level

300

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相关类别

Application

黄曲霉毒素 B1 是一种致癌化合物，在 p53 抑癌基因的 249 位密码子处诱导 G 转化为 T。 在检测食品中的黄曲霉毒素污染时，黄曲霉毒素 B1 可用作内标。

Biochem/physiol Actions

黄曲霉毒素 B1 是由黄曲霉（一种常见的土壤真菌）产生的致癌化合物，在 p53 抑癌基因第 249 位密码子处可诱导 G 转化为 T。黄曲霉毒素 B1 是食品污染物和肝致癌物。黄曲霉毒素通过 P450 I 期酶（主要是 CYP3A4）经黄曲霉毒素 B1 3-羟基化反应生物转化为遗传毒性中间体。排毒取决于 II 期酶，例如谷胱甘肽 S-转移酶和 AFB（1）-醛还原酶（AFAR）。黄曲霉毒素 B1 是 CYP1A2、CYP2A6、CYP2D6 和 CYP3A 家族的底物。

Disclaimer

可能致癌.

General description

我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“预防废弃物”、“设计更安全的化学品和产品”和“节能设计”绿色化学原则方面取得了重大改进。 点击此处查看其 DOZN 记分卡。

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - Carc. 1B - Muta. 1B

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

高风险级别生物产品--毒素类产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000486553
0000486553
0000477743
0000477743
0000460656

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Hajar Zolfaghari et al.
Advanced pharmaceutical bulletin, 10(3), 482-487 (2020-07-16)
Purpose: The present study was conducted to assess the ability of probiotic bacteria and yeasts strains to reduce aflatoxin B1 (AFB1) in gastrointestinal simulated conditions. Aflatoxins are potent carcinogenic and immunosuppressive agents. Acute exposure to a high level of aflatoxins
Ilenia Siciliano et al.
Toxins, 7(3), 743-754 (2015-03-10)
Fungi belonging to the genus Alternaria are common pathogens of fruit and vegetables with some species able to produce secondary metabolites dangerous to human health. Twenty-eight Alternaria isolates from rocket and cabbage were investigated for their mycotoxin production. Five different
Andre Barany et al.
Animals : an open access journal from MDPI, 11(3) (2021-04-04)
Several studies in fish have shown that aflatoxin B1 (AFB1) causes a disparity of species-dependent physiological disorders without compromising survival. We studied the effect of dietary administration of AFB1 (2 mg AFB1 kg-1 diet) in gilthead seabream (Sparus aurata) juveniles
Rahul R Bhowate et al.
Journal of oral and maxillofacial pathology : JOMFP, 25(1), 110-117 (2021-08-06)
Areca nut is deeply rooted sociocultural habit in India. Areca nut reported to be infested by fungi during the field and storage conditions. Areca nut alkaloids, nitrosamines, tobacco and aflatoxin are cytotoxic, immunotoxic to red blood cell and epithelial cell.
Fernanda Cosme et al.
Foods (Basel, Switzerland), 9(12) (2020-12-06)
Aflatoxins B1 and B2 are two highly toxic mycotoxins that have been sometimes found in wines. Currently, no technological solution is available to reduce or eliminate aflatoxins from wines when they are present. Therefore, this work aims to study the
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Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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