推荐产品
质量水平
检测方案
≥99%
形式
powder
mp
140-143 °C (lit.)
溶解性
water: 50 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
[Br-].CC(=O)OCC[N+](C)(C)C
InChI
1S/C7H16NO2.BrH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChI key
ZEHGKSPCAMLJDC-UHFFFAOYSA-M
基因信息
human ... CHRM3(1131)
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应用
乙酰胆碱是胆碱能突触的内源性神经递质，可放大肌膜的动作电位，从而诱导肌肉收缩。溴化乙酰胆碱可用作乙酰胆碱受体激动剂，以鉴定、表征和区分胆碱能受体的类型。溴化乙酰胆碱可用作抑制剂，以鉴定和表征天然和突变的丁酰胆碱酯酶。
生化/生理作用
胆碱能突触中的内源性神经递质，通过增强肌膜动作电位来触发肌肉收缩反应。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Scott A Hollingsworth et al.
Nature communications, 10(1), 3289-3289 (2019-07-25)
Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly given recent structures that reveal
Rahini Kakumanu et al.
Toxins, 11(4) (2019-04-04)
Russell's viper (Daboia russelii) venom causes a range of clinical effects in humans. Hypotension is an uncommon but severe complication of Russell's viper envenoming. The mechanism(s) responsible for this effect are unclear. In this study, we examined the cardiovascular effects
James A Angus et al.
European journal of pharmacology, 804, 111-116 (2017-03-17)
Endothelin receptor antagonists are approved for pulmonary arterial hypertension. Development of selective ET Human isolated pulmonary (i.d. 5.5mm) and human radial (i.d. 3.23mm) artery ring segments were mounted in organ baths for isometric force measurement. Single concentration-contraction curves to endothelin-1
Li-Yan Zhao et al.
Acta pharmacologica Sinica, 39(5), 875-884 (2018-03-30)
Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. (No 2508). We previously showed that Xyl-B promoted endothelial NO release and protected against atherosclerosis through the Akt/eNOS pathway. Vascular NO production regulates vasoconstriction in central
Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta.
Lu Gan et al.
Acta pharmacologica Sinica, 37(12), 1555-1562 (2016-09-13)
Ginsenosides are considered to be the major pharmacologically active ginseng constituents, whereas 20(S)-protopanaxadiol [20(S)-PPD] is the active metabolite of ginsenosides in gut. In this study we investigated the effect of 20(S)-PPD on isolated rat thoracic aortas as well as its
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