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Merck
CN
所有图片(1)

文件

A6469

Sigma-Aldrich

Apelin-13 三氟乙酸盐

≥95%

别名:

Prepro-65-77-Apelin

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About This Item

经验公式（希尔记法）:
C69H111N23O16S · C2F3O2
分子量:
1663.84
UNSPSC代码:
12352202
PubChem化学物质编号:
329770894
NACRES:
NA.32

质量水平

200

检测方案

≥95%

形式

powder

UniProt登记号

Q9ULZ1

储存温度

−20°C

SMILES字符串

OC(=O)C(F)(F)F.CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(O)=O

InChI

1S/C69H111N23O16S.C2HF3O2/c1-39(2)32-47(86-58(98)44(17-9-26-78-68(73)74)83-63(103)52-20-12-29-91(52)65(105)45(18-10-27-79-69(75)76)84-56(96)42(71)22-23-54(72)94)59(99)89-50(37-93)61(101)87-48(34-41-35-77-38-81-41)60(100)82-43(16-7-8-25-70)57(97)80-36-55(95)90-28-11-19-51(90)62(102)85-46(24-31-109-3)66(106)92-30-13-21-53(92)64(104)88-49(67(107)108)33-40-14-5-4-6-15-40;3-2(4,5)1(6)7/h4-6,14-15,35,38-39,42-53,93H,7-13,16-34,36-37,70-71H2,1-3H3,(H2,72,94)(H,77,81)(H,80,97)(H,82,100)(H,83,103)(H,84,96)(H,85,102)(H,86,98)(H,87,101)(H,88,104)(H,89,99)(H,107,108)(H4,73,74,78)(H4,75,76,79);(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-;/m0./s1

InChI key

IUOVYCLNUOUEHV-PDGAQFIRSA-N

基因信息

human ... APLN(8862)

Amino Acid Sequence

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe

一般描述

爱帕琳肽是一种调节肽，同时也是APJ受体的配体。它是G蛋白偶联受体家族的一员。爱帕琳肽和APJ在体内分布广泛。

应用

爱帕琳肽-13三氟乙酸盐已被用于确定爱帕琳肽是否通过诱导足细胞功能障碍而促进糖尿病性肾病（DN）的进展。它还被用于考察爱帕琳肽对心肌梗死（MI）损伤的作用及其具体机制。

生化/生理作用

合成内源肽激动剂用于人APJ受体这种与血管紧张素受体（AT1）相关的推测受体蛋白。该肽在表达APJ受体的CHO细胞中发挥酸化率促进活性，其中值有效浓度（EC50）值为0.37nM。阻止HIV-1和HIV-2进入表达APJ受体的细胞。
爱帕琳肽对于许多内脏器官的细胞保护作用起一定的生理作用。它可用于治疗胰岛素抵抗和高血压，但也可用作负因子。爱帕琳肽还可调节心血管疾病。

其他说明

从0.1％TFA水溶液中冻干

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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M X Zou et al.
FEBS letters, 473(1), 15-18 (2000-05-10)
The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains. We have determined that some HIV and SIV strains use APJ as a coreceptor to infect the
Ewa Mlyczyńska et al.
International journal of molecular sciences, 22(5) (2021-04-04)
Previously, we demonstrated the expression of apelin and G-protein-coupled receptor APJ in human placenta cell lines as well as its direct action on placenta cell proliferation and endocrinology. The objective of this study was to examine the effect of apelin
Jiming Yin et al.
Cell death & disease, 9(10), 1031-1031 (2018-10-12)
The epithelial-mesenchymal transition (EMT) of podocytes had been reported to be involved in the glomerular fibrosis in diabetic kidney diseases, which was regulated by TGFβ and NFκB pathways. And apelin, an adipokine which is upregulated in diabetic kidney diseases, was
Apelin promotes diabetic nephropathy by inducing podocyte dysfunction via inhibiting proteasome activities.
Guo C
Journal of Cellular and Molecular Medicine, 19(9), 2273-2285 (2015)
D K Lee et al.
Journal of neurochemistry, 74(1), 34-41 (2000-01-05)
The apelin peptide was recently discovered and demonstrated to be the endogenous ligand for the G protein-coupled receptor, APJ. A search of the GenBank databases retrieved a rat expressed sequence tag partially encoding the preproapelin sequence. The GenBank search also
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