所有图片(1)
别名:
Adiponectin Antibody, Anti-Adiponectin antibody produced in rabbit, Anti-Adipocyte Complement-Related Protein of 30 kDa
推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
mouse, human
浓度
~1 mg/mL
技术
western blot (chemiluminescent): 0.5-1 μg/mL using using human plasma or placenta, or an extract of differentiated 3T3-L1 mouse cells. (It is recommended to dilute the antibody in phosphate buffered saline containing 0.5% non-fat dry milk for background staining reduction.)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ADIPOQ(9370)
mouse ... Adipoq(11450)
一般描述
Adiponectin is secreted from adipose tissue for the regulation of glucose and fatty acid break down.
Anti-Adiponectin is produced in rabbit using a synthetic peptide corresponding to amino acid residues of human adiponectin. Adiponectin, also designated as adipocyte complement-related protein of 30 kDa (Acrp30), AdipoQ, apM1, Gelatin-binding protein 28 kDa (GBP28) is an adipocyte-specific protein that circulates in the blood stream, where it accounts for approximately 0.01% of all plasma proteins. Adiponectin belongs to the complement factor C1q family that belongs to the soluble defense collagen superfamily. Adiponectin (ADIPOQ) protein has a carboxyl-terminal globular domain and an amino-terminal collagen domain.
特异性
Rabbit Anti-Adiponectin antibody recognizes human and mouse adiponectin.
免疫原
synthetic peptide corresponding to amino acid residues 225-244 of human adiponectin with N-terminal added cysteine, conjugated to KLH.
应用
Anti-Adiponectin antibody produced in rabbit has been used in western blotting and immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Rabbit Anti-Adiponectin antibody has been used for immunohistochemical and western blot applications.
生化/生理作用
Adipose tissue has important roles in energy storage, glucose homeostasis and fat metabolism.(10) Increased adiponectin levels are associated with type I diabetes mellitus, anorexia nervosa, weight reduction, and chronic renal failure. Adiponectin (ADIPOQ) affects lipid catabolism by increasing fatty acid oxidation in muscle, modulates glucose uptake, alters liver gluconeogenesis and enhances insulin-sensitivity in both muscle and liver. ADIPOQ has anti-atherosclerotic and anti-inflammatory properties. ADIPOQ has a role in physiological processes such as energy homeostasis and obesity. Low levels of adiponectin are also linked with hypertension and dyslipidemia. Mutation in the gene encoding it is linked with risk for endometrial cancer.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Caroline Fernandes-Santos et al.
Nutrition (Burbank, Los Angeles County, Calif.), 25(7-8), 818-827 (2009-03-10)
We analyzed the effect of peroxisome proliferator-activated receptor (PPAR) agonists on adipose tissue morphology, adiponectin expression, and its relation to glucose and insulin levels in C57BL/6 mice fed a high-fat high-sucrose (HFHS) diet. Male C57BL/6 mice received one of five
P A Nidhina Haridas et al.
The Journal of clinical endocrinology and metabolism, 100(10), E1299-E1307 (2015-07-24)
Circulating ANGPTL8 has recently been used as a marker of insulin action. We studied expression and insulin regulation of ANGPTL8 and ANGPTL3 in vivo and in vitro. Expression of ANGPTL8 and ANGPTL3 was studied in 34 paired samples of human
Deborah K Oh et al.
Diabetes, obesity & metabolism, 9(3), 282-289 (2007-03-30)
Adipose tissue is an active metabolic tissue that secretes multiple metabolically important proteins, known as adipokines. Adiponectin is an important adipokine because of its beneficial effects on glucose and lipid metabolism. Low levels of adiponectin are associated with disease states
Eicosapentaenoic acid (EPA) vs. Docosahexaenoic acid (DHA): Effects in epididymal white adipose tissue of mice fed a high-fructose diet
Bargut TCL, et al.
Prostaglandins, Leukotrienes, and Essential Fatty Acids, 123, 14-24 (2017)
K Yuan et al.
Journal of dairy science, 97(6), 3822-3831 (2014-04-16)
The objective of this study was to evaluate effects of chromium propionate (CrPr), rumen-protected lysine and methionine (RPLM), or both on metabolism, neutrophil function, and adipocyte size in lactating dairy cows (38 ± 15 d in milk). Forty-eight individually fed
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