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Merck
CN

A6106

Aprotinin

BioUltra, 3-8 TIU/mg solid, powder, ≥98% (SDS-PAGE), suitable for inhibition assay

别名:

BPTI, 抑肽酶, 牛胰胰蛋白酶抑制剂, 胰蛋白酶抑制剂（碱性）

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关于此项目

经验公式（希尔记法）:
C284H432N84O79S7
化学文摘社编号:
9087-70-1
分子量:
6511.44
UNSPSC Code:
12352204
NACRES:
NA.77
EC Number:
232-994-9
MDL number:
MFCD00130541

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产品名称

抑肽酶 来源于牛肺, BioUltra, 3-8 TIU/mg solid, ≥98% (SDS-PAGE)

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI

1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(41

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

biological source

bovine lung

product line

BioUltra

assay

≥98% (SDS-PAGE)

form

powder

specific activity

3-8 TIU/mg solid

mol wt

~6,500

technique(s)

inhibition assay: suitable

solubility

H2O: 5 mg/mL, clear to very slightly hazy

UniProt accession no.

P00974

storage temp.

2-8°C

Quality Level

300

Gene Information

cow ... PTI(404172)

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相关类别

Application

抑肽酶被大量用作胰蛋白酶抑制剂。

Biochem/physiol Actions

抑肽酶是一种竞争性丝氨酸蛋白酶抑制剂，可与酶的活性位点组成稳定的复合酶并同时对其进行封闭。 这种结合是可逆的，而且绝大多数抑肽酶-蛋白酶复合物可在极端的pH >10 or < 3水平时发生解离。 从结构上来说，抑肽酶是一种来自牛肺的单体球状蛋白，由58个氨基酸组成并排列在具有三个交联二硫键的单个多肽链中。

Other Notes

一个胰蛋白酶抑制剂单位 (TIU) 将使 2 个胰蛋白酶单位的活性下降 50%，其中 1 个胰蛋白酶单位将在 25°C pH 7.8 下每分钟水解 1.0 μmol 的 N-α-苯甲酰-DL-精氨酸对硝基苯胺 (BAPNA)。
一个胰蛋白酶抑制剂单位（TIU）可将两个胰蛋白酶单位的活性降低50％，而其中一个胰蛋白酶单位在pH 7.8和25℃下可每分钟水解1.0 μ摩尔的N-α-苯甲酰基-DL-精氨酸对硝基苯胺。另一种常用的单位是KIU，而1 TIU = 1,300 KIU。

Preparation Note

进一步纯化 A1153，得到活性和纯度略高的产物

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品
低风险生物材料
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000511429
0000511429
0000477864
0000477863
0000477864

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商品

Aprotinin

While aprotinin and bovine pancreatic trypsin inhibitor (BPTI) are the same protein sequence, the term aprotinin is typically used when describing the protein derived from bovine lung.

实验方案

Enzymatic Assay of Aprotinin

Objective: To standardize a procedure for the enzymatic assay of Aprotinin.

抑肽酶酶活测定

抑肽酶是一种牛胰蛋白酶抑制剂。在测定抑肽酶活性时，该测定使用了在405 nm下的连续分光光度法进行测定。

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